Non-sendromic interlobular paucity appearing in adolesant age: Case report

Interlobular paucity (ILP) is a disease characterized lower cholestatic chanels as well as hepatocellular giant cell transformation or/and fibrosis. A 14 year-old boy was referred us for itching, jaundice and weight loss for 3 months. On examination, both sclera were icteric. Laboratory analysis rev...

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Bibliographic Details
Published in:Gülhane Tip Dergisi 2015-09, Vol.57 (3), p.315
Main Authors: BALAMTEKİN, Necati, EKSERT, Sami, Mustafa GÜLGÜN, KARSLIOĞLU, Yıldırım, KARAOĞLU, Abdülbaki
Format: Article
Language:eng ; tur
Subjects:
Antibodies
Biopsy
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Summary:Interlobular paucity (ILP) is a disease characterized lower cholestatic chanels as well as hepatocellular giant cell transformation or/and fibrosis. A 14 year-old boy was referred us for itching, jaundice and weight loss for 3 months. On examination, both sclera were icteric. Laboratory analysis revealed alanin aminotransferase 178 IU, aspartat amino transferase 89 IU, total/direct bilirubine:5.5/3.9 mg/dl, anti Hepatitis A Virus IgA and IgG negative, HBs Ag negative, anti HBs pozitive, anti HCV negative, AntiHIV negative, antinuclear antibody negative, anti double strand DNA negative, anti smooth muscle antibody negative, anti mitochondrial antibody negative and anti liver kidney antibody negative. Copper in 24 hour urine and seruloplasmine were normal. Liver biopsy showed lower interlobular cholestatic chanels and hepatocellular giant cell transformation. Phsycians should not delay for liver biopsy to diagnosis of interlobular paucity in adolescents with cholestatic signs if there is no primary disease for cholestasis.
ISSN:1302-0471
2146-8052
DOI:10.5455/gulhane.42885