Cedrol protects against chronic constriction injury-induced neuropathic pain through inhibiting oxidative stress and inflammation

• Published in: Metabolic brain disease 2020-10, Vol.35 (7), p.1119-1126
• Main Authors: Sakhaee, Mohammad Hossein, Sayyadi, Seyed Amir Hossein, Sakhaee, Nader, Sadeghnia, Hamid R., Hosseinzadeh, Hossein, Nourbakhsh, Fahimeh, Forouzanfar, Fatemeh
• Format: Article
• Language: English
• Subjects: Acetone; Animals; Attenuation; Biochemistry; Biomarkers; Biomedical and Life Sciences; Biomedicine; Constrictions; Hypersensitivity; Inflammation; Inflammation - drug therapy; Inflammation - metabolism; Inflammatory response; Injuries; Injury analysis; Interleukin 6; Interleukin-6 - metabolism; Male; Malondialdehyde; Malondialdehyde - metabolism; Metabolic Diseases; Nervous system; Neuralgia; Neuralgia - metabolism; Neuralgia - prevention & control; Neurology; Neurosciences; Oncology; Original Article; Oxidative stress; Oxidative Stress - drug effects; Pain; Pain Threshold - drug effects; Polycyclic Sesquiterpenes - pharmacology; Polycyclic Sesquiterpenes - therapeutic use; Protective Agents - pharmacology; Protective Agents - therapeutic use; Rats; Rats, Wistar; Sensory Receptor Cells - drug effects; Sensory Receptor Cells - metabolism; Spinal cord; Spinal Cord - drug effects; Spinal Cord - metabolism; Sulfhydryl Compounds - metabolism; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Tumors
• ISSN: 0885-7490; 1573-7365
• DOI: 10.1007/s11011-020-00581-8

Injured somatosensory nervous system cause neuropathic pain which is quite difficult to treat using current approaches. It is therefore important to find new therapeutic options. We have analyzed cedrol effect on chronic constriction injury (CCI) induced neuropathic pain in rats. The mechanical and thermal hypersensitivity were evaluated using the von Frey filament, radiant heat and acetone drop methods. The changes in the levels of biomarkers of oxidative stress including malondialdehyde (MDA) and total thiol (SH), as well as inflammatory mediators including Tumour Necrosis Factor alpha (TNF-α) and Interleukin 6 (IL-6) were estimated in the lumbar portion (L4–L6) of neuropathic rats. Administration of cedrol attenuated the CCI-induced mechanical and thermal hypersensitivity. CCI produced an increase in MDA along with a reduction in SH levels in the spinal cord of the CCI rats. Reduced levels of SH were restored by cedrol. Also, the levels of MDA were reduced in the cedrol-treated CCI rats compared to the untreated CCI rats. Besides, level of TNF-α and IL-6 increased in the spinal cord of CCI group and cedrol could reverse it. The current study showed that cedrol attenuates neuropathic pain in CCI rats by inhibition of inflammatory response and attenuation of oxidative stress.