Lactoferrin Coating Improves the Antibacterial and Osteogenic Properties of Alkali-Treated Titanium with Nanonetwork Structures

Titanium and its alloys are the main dental implant materials used at present. The biological properties of pure titanium can be further improved by surface treatment methods. Alkali treatment of pure titanium at room temperature can form nanonetwork structures (TNS) on the surface, which has better...

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Bibliographic Details
Published in:Journal of nanomaterials 2020, Vol.2020 (2020), p.1-13
Main Authors: Sui, Wen, Kawazoe, Takayoshi, Okazaki, Joji, Nishizaki, Hiroshi, Yan, Sifan, Zhang, Honghao, Yang, Yuanyuan, Komasa, Satoshi, Chen, Luyuan, Hong, Yonglong, Yin, Derong, Kusumoto, Tetsuji
Format: Article
Language:English
Subjects:
Alloys
Antimicrobial agents
Bacteria
Bacterial diseases
Biofilms
Biological properties
Biomedical materials
Cell adhesion & migration
Composite materials
Dental alloys
Dental implants
Dental materials
Ethanol
Experiments
Fourier transforms
Heat
Homeostasis
Metabolism
Microscopy
Nanomaterials
Physiology
Researchers
Room temperature
Surface treatment
Surgical implants
Titanium
Titanium base alloys
Topography
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Summary:Titanium and its alloys are the main dental implant materials used at present. The biological properties of pure titanium can be further improved by surface treatment methods. Alkali treatment of pure titanium at room temperature can form nanonetwork structures (TNS) on the surface, which has better osteoinductive ability than pure titanium. However, TNS does not possess antimicrobial properties, and bacterial infection is one of the main reasons for the failure of dental implant therapy. Therefore, it was the focus of our research to endow TNS with certain antimicrobial properties on the premise of maintaining its osteoinductive ability. Because of its excellent broad-spectrum antimicrobial properties and because it promotes osteoblast-like cell growth, lactoferrin (LF) was considered a promising prospect as a surface biological treatment material. In this study, bovine LF of physiological concentration was successfully coated on the surface of TNS to form the TNS-LF composite material. Results from in vitro and in vivo experiments showed that TNS-LF had better osteoinductive ability than TNS. Bacterial attachment and biofilm formation were also significantly decreased on the surface of TNS-LF. Therefore, this study has provided an experimental basis for the development of osteoinduction-antimicrobial composite implant materials for dental applications.
ISSN:1687-4110
1687-4129
DOI:10.1155/2020/2516975