Tacrolimus treatment in childhood refractory nephrotic syndrome: A retrospective study on efficacy, therapeutic drug monitoring, and contributing factors to variable blood tacrolimus levels

•Children carrying CYP3A5*3 with higher body weight had a higher C0/Dose.•Routine CYP3A5 genotyping test played a minor role in

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Bibliographic Details
Published in:International immunopharmacology 2020-04, Vol.81, p.106290, Article 106290
Main Authors: Guo, Hong-Li, Xu, Jing, Sun, Jie-Yu, Li, Ling, Guo, Hui-Lei, Jing, Xia, Xu, Ze-Yue, Hu, Ya-Hui, Xu, Ze-Jun, Sun, Fang, Ding, Xuan-Sheng, Chen, Feng, Zhao, Fei
Format: Article
Language:English
Subjects:
Adolescent
Blood
Blood levels
Body weight
C0/Dose
Child
Child, Preschool
Children
CYP3A5
Cytochrome P-450 CYP3A - genetics
Dosage
Drug dosages
Drug Therapy, Combination
Exposure
Female
Follow-Up Studies
Genotype
Genotyping
Humans
Immunosuppressive agents
Immunosuppressive Agents - therapeutic use
Infant
Kidney diseases
Male
Monitoring, Physiologic
Nephrotic syndrome
Nephrotic Syndrome - drug therapy
Pediatric
Pharmacokinetics
Polymorphism, Genetic
Prednisone
Prednisone - therapeutic use
Refractory nephrotic syndrome
Remission
Retrospective Studies
Tacrolimus
Tacrolimus - blood
Tacrolimus - therapeutic use
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Description
Summary:•Children carrying CYP3A5*3 with higher body weight had a higher C0/Dose.•Routine CYP3A5 genotyping test played a minor role in
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2020.106290