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Pathology protocol increases lymph node yield in neck dissection for oral cavity squamous cell carcinoma
Background Lymph node yield (LNY) is a proposed quality indicator in neck dissection for oral cavity squamous cell carcinoma (OCSCC). Methods Retrospective series including 190 patients with OCSCC undergoing neck dissection between 2016 and 2018. A change in pathologic grossing protocol was initiate...
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| Published in: | Head & neck 2020-10, Vol.42 (10), p.2872-2879 |
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| container_end_page | 2879 |
| container_issue | 10 |
| container_start_page | 2872 |
| container_title | Head & neck |
| container_volume | 42 |
| creator | Holcomb, Andrew J. Perryman, Mollie Goodwin, Sara Penn, Joseph Villwock, Mark R. Bur, Andrés M. Shnayder, Yelizaveta Tsue, Terance T. Woodroof, Janet Kakarala, Kiran |
| description | Background
Lymph node yield (LNY) is a proposed quality indicator in neck dissection for oral cavity squamous cell carcinoma (OCSCC).
Methods
Retrospective series including 190 patients with OCSCC undergoing neck dissection between 2016 and 2018. A change in pathologic grossing protocol was initiated during the study period to assess residual adipose tissue. A generalized linear model was used to assess the impact of multiple variables on LNY.
Results
Mean LNY was 28.59 (SD = 17.65). The protocol identified a mean of 10.32 lymph nodes per case. Multivariable analysis identified associations between LNY and use of the pathology protocol (P = .02), number of dissected lymph node levels (P |
| doi_str_mv | 10.1002/hed.26343 |
| format | article |
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Lymph node yield (LNY) is a proposed quality indicator in neck dissection for oral cavity squamous cell carcinoma (OCSCC).
Methods
Retrospective series including 190 patients with OCSCC undergoing neck dissection between 2016 and 2018. A change in pathologic grossing protocol was initiated during the study period to assess residual adipose tissue. A generalized linear model was used to assess the impact of multiple variables on LNY.
Results
Mean LNY was 28.59 (SD = 17.65). The protocol identified a mean of 10.32 lymph nodes per case. Multivariable analysis identified associations between LNY and use of the pathology protocol (P = .02), number of dissected lymph node levels (P < .001), presence of pathologic lymph nodes (P = .002), body mass index (P = .02), prior neck surgery (P = .001), and prior neck radiation (P = .001).
Conclusions
Assessment of residual adipose tissue within neck dissection specimens improves accuracy of LNY. LNY in neck dissection is influenced by multiple factors including methods of pathologic assessment.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.26343</identifier><identifier>PMID: 32578921</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Adipose tissue ; Body mass index ; Dissection ; Generalized linear models ; Head & neck cancer ; Head and neck ; head and neck cancer ; histopathology ; Lymph nodes ; Lymphatic system ; Neck ; neck dissection ; Oral cancer ; Oral cavity ; Quality control ; quality indicators ; Squamous cell carcinoma ; Surgery</subject><ispartof>Head & neck, 2020-10, Vol.42 (10), p.2872-2879</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4233-6950e5780c50ef4f266f090bfa452dd78328292407e2f25c1b0431af2599c69b3</citedby><cites>FETCH-LOGICAL-c4233-6950e5780c50ef4f266f090bfa452dd78328292407e2f25c1b0431af2599c69b3</cites><orcidid>0000-0001-6879-6453 ; 0000-0001-8397-2312</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32578921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Holcomb, Andrew J.</creatorcontrib><creatorcontrib>Perryman, Mollie</creatorcontrib><creatorcontrib>Goodwin, Sara</creatorcontrib><creatorcontrib>Penn, Joseph</creatorcontrib><creatorcontrib>Villwock, Mark R.</creatorcontrib><creatorcontrib>Bur, Andrés M.</creatorcontrib><creatorcontrib>Shnayder, Yelizaveta</creatorcontrib><creatorcontrib>Tsue, Terance T.</creatorcontrib><creatorcontrib>Woodroof, Janet</creatorcontrib><creatorcontrib>Kakarala, Kiran</creatorcontrib><title>Pathology protocol increases lymph node yield in neck dissection for oral cavity squamous cell carcinoma</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Lymph node yield (LNY) is a proposed quality indicator in neck dissection for oral cavity squamous cell carcinoma (OCSCC).
Methods
Retrospective series including 190 patients with OCSCC undergoing neck dissection between 2016 and 2018. A change in pathologic grossing protocol was initiated during the study period to assess residual adipose tissue. A generalized linear model was used to assess the impact of multiple variables on LNY.
Results
Mean LNY was 28.59 (SD = 17.65). The protocol identified a mean of 10.32 lymph nodes per case. Multivariable analysis identified associations between LNY and use of the pathology protocol (P = .02), number of dissected lymph node levels (P < .001), presence of pathologic lymph nodes (P = .002), body mass index (P = .02), prior neck surgery (P = .001), and prior neck radiation (P = .001).
Conclusions
Assessment of residual adipose tissue within neck dissection specimens improves accuracy of LNY. LNY in neck dissection is influenced by multiple factors including methods of pathologic assessment.</description><subject>Adipose tissue</subject><subject>Body mass index</subject><subject>Dissection</subject><subject>Generalized linear models</subject><subject>Head & neck cancer</subject><subject>Head and neck</subject><subject>head and neck cancer</subject><subject>histopathology</subject><subject>Lymph nodes</subject><subject>Lymphatic system</subject><subject>Neck</subject><subject>neck dissection</subject><subject>Oral cancer</subject><subject>Oral cavity</subject><subject>Quality control</subject><subject>quality indicators</subject><subject>Squamous cell carcinoma</subject><subject>Surgery</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kDFPwzAQhS0EoqUw8AeQJSaG0IvtOMmISqFIlWCAOXIch6Q4cWsnoPx7XNKOTPd09-nd3UPoOoT7EIDMK1XcE04ZPUHTENI4AMri071mNKAQswm6cG4DAJQzco4mlERxkpJwiqo30VVGm88Bb63pjDQa1620SjjlsB6abYVbUyg81EoXfoRbJb9wUTunZFebFpfGYmOFxlJ8192A3a4Xjekdlkrvm1bWrWnEJTorhXbq6lBn6ONp-b5YBevX55fFwzqQjFAa8DQC5Y8D6WvJSsJ5CSnkpWARKYo4oSQhKWEQK1KSSIa5_zEUXqap5GlOZ-h29PXv7Hrlumxjetv6lRlhDDgknHFP3Y2UtMY5q8psa-tG2CELIdtnmvlMs79MPXtzcOzzxneP5DFED8xH4KfWavjfKVstH0fLX4NngEY</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Holcomb, Andrew J.</creator><creator>Perryman, Mollie</creator><creator>Goodwin, Sara</creator><creator>Penn, Joseph</creator><creator>Villwock, Mark R.</creator><creator>Bur, Andrés M.</creator><creator>Shnayder, Yelizaveta</creator><creator>Tsue, Terance T.</creator><creator>Woodroof, Janet</creator><creator>Kakarala, Kiran</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0001-6879-6453</orcidid><orcidid>https://orcid.org/0000-0001-8397-2312</orcidid></search><sort><creationdate>202010</creationdate><title>Pathology protocol increases lymph node yield in neck dissection for oral cavity squamous cell carcinoma</title><author>Holcomb, Andrew J. ; Perryman, Mollie ; Goodwin, Sara ; Penn, Joseph ; Villwock, Mark R. ; Bur, Andrés M. ; Shnayder, Yelizaveta ; Tsue, Terance T. ; Woodroof, Janet ; Kakarala, Kiran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4233-6950e5780c50ef4f266f090bfa452dd78328292407e2f25c1b0431af2599c69b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adipose tissue</topic><topic>Body mass index</topic><topic>Dissection</topic><topic>Generalized linear models</topic><topic>Head & neck cancer</topic><topic>Head and neck</topic><topic>head and neck cancer</topic><topic>histopathology</topic><topic>Lymph nodes</topic><topic>Lymphatic system</topic><topic>Neck</topic><topic>neck dissection</topic><topic>Oral cancer</topic><topic>Oral cavity</topic><topic>Quality control</topic><topic>quality indicators</topic><topic>Squamous cell carcinoma</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Holcomb, Andrew J.</creatorcontrib><creatorcontrib>Perryman, Mollie</creatorcontrib><creatorcontrib>Goodwin, Sara</creatorcontrib><creatorcontrib>Penn, Joseph</creatorcontrib><creatorcontrib>Villwock, Mark R.</creatorcontrib><creatorcontrib>Bur, Andrés M.</creatorcontrib><creatorcontrib>Shnayder, Yelizaveta</creatorcontrib><creatorcontrib>Tsue, Terance T.</creatorcontrib><creatorcontrib>Woodroof, Janet</creatorcontrib><creatorcontrib>Kakarala, Kiran</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Holcomb, Andrew J.</au><au>Perryman, Mollie</au><au>Goodwin, Sara</au><au>Penn, Joseph</au><au>Villwock, Mark R.</au><au>Bur, Andrés M.</au><au>Shnayder, Yelizaveta</au><au>Tsue, Terance T.</au><au>Woodroof, Janet</au><au>Kakarala, Kiran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathology protocol increases lymph node yield in neck dissection for oral cavity squamous cell carcinoma</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2020-10</date><risdate>2020</risdate><volume>42</volume><issue>10</issue><spage>2872</spage><epage>2879</epage><pages>2872-2879</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Lymph node yield (LNY) is a proposed quality indicator in neck dissection for oral cavity squamous cell carcinoma (OCSCC).
Methods
Retrospective series including 190 patients with OCSCC undergoing neck dissection between 2016 and 2018. A change in pathologic grossing protocol was initiated during the study period to assess residual adipose tissue. A generalized linear model was used to assess the impact of multiple variables on LNY.
Results
Mean LNY was 28.59 (SD = 17.65). The protocol identified a mean of 10.32 lymph nodes per case. Multivariable analysis identified associations between LNY and use of the pathology protocol (P = .02), number of dissected lymph node levels (P < .001), presence of pathologic lymph nodes (P = .002), body mass index (P = .02), prior neck surgery (P = .001), and prior neck radiation (P = .001).
Conclusions
Assessment of residual adipose tissue within neck dissection specimens improves accuracy of LNY. LNY in neck dissection is influenced by multiple factors including methods of pathologic assessment.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>32578921</pmid><doi>10.1002/hed.26343</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6879-6453</orcidid><orcidid>https://orcid.org/0000-0001-8397-2312</orcidid></addata></record> |
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| ispartof | Head & neck, 2020-10, Vol.42 (10), p.2872-2879 |
| issn | 1043-3074 1097-0347 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adipose tissue Body mass index Dissection Generalized linear models Head & neck cancer Head and neck head and neck cancer histopathology Lymph nodes Lymphatic system Neck neck dissection Oral cancer Oral cavity Quality control quality indicators Squamous cell carcinoma Surgery |
| title | Pathology protocol increases lymph node yield in neck dissection for oral cavity squamous cell carcinoma |
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