Synthesis and Primary Antitumor Screening of 4-[5-(1H-Indol-3-ylmethylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanamides

A preparative procedure was developed for the synthesis of 4-[5-(1-R-1 H -indol-3-ylmethylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acids which were converted to acid chlorides, and the latter reacted with aromatic and heterocyclic amines to afford a series of previously unknown 4-[...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2020-07, Vol.56 (7), p.1146-1152
Main Authors: Horishny, V. Ya, Matiychuk, V. S.
Format: Article
Language:English
Subjects:
Anticancer properties
Chemistry
Chemistry and Materials Science
Heterocyclic amines
Organic Chemistry
Synthesis
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Summary:A preparative procedure was developed for the synthesis of 4-[5-(1-R-1 H -indol-3-ylmethylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acids which were converted to acid chlorides, and the latter reacted with aromatic and heterocyclic amines to afford a series of previously unknown 4-[5-(1 H -indol-3-ylmethylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanamides. The synthesized compounds showed a moderate antitumor activity against most malignant tumor cells. UO31 renal cancer cell line turned out to be most sensitive to most of the tested compounds.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428020070040