A systemic review on floating mucoadhesive drug delivery system and its present scenario

The drugs which have local action or those which have maximum absorption in gastric pH require increased duration of stay in GIT. [...]floating and mucoadhesive drug delivery systems are advantageous in increasing the bioavailability and enhanced therapeutic activity. [...]patients should not be dos...

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Bibliographic Details
Published in:Research journal of pharmacy and technology 2020-09, Vol.13 (9), p.4509-4516
Main Authors: Jagdish, K Arun, Pattanayak, Dharmajit, Shrivastava, B., Adepu, Ramesh
Format: Article
Language:English
Subjects:
Bioavailability
Cellulose
Drug delivery systems
Drug dosages
Fluids
Polymers
Stomach
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Summary:The drugs which have local action or those which have maximum absorption in gastric pH require increased duration of stay in GIT. [...]floating and mucoadhesive drug delivery systems are advantageous in increasing the bioavailability and enhanced therapeutic activity. [...]patients should not be dosed with floating forms just before going to bed.6 Types of FDDS(7-9) (A) Non-effervescent systems: [...]the product floats on the gastric fluid while releasing the drug gradually over a prolonged duration. The potential benefits include increased bioavailability; predictable, reproducible and generally short gastric residence time, no risk of dose dumping; reduced risk of local irritation, and the flexibility to blend pellets with different compositions or release patterns. Because of their smaller particle size these systems are capable of passing through the GI tract easily, leading to less interand intra-subject variability.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2020.00795.7