Skin Photosensitivity is Associated with 25-Hydroxyvitamin D and BMD but not Fractures Independent of Melanin Density in Older Caucasian Adults

Whether skin photosensitivity modulates sun exposure behaviours, consequent vitamin D status and skeletal health outcomes independently of constitutive pigmentation have not been systematically investigated. 1072 community-dwelling adults aged 50–80 years had skin photosensitivity quantified by ques...

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Bibliographic Details
Published in:Calcified tissue international 2020-10, Vol.107 (4), p.335-344
Main Authors: Thompson, M. J. W., Jones, G., Balogun, S. A., Aitken, D. A.
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Biochemistry
Biomedical and Life Sciences
Bone mineral density
Cell Biology
Complications
Dual energy X-ray absorptiometry
Endocrinology
Environmental factors
Fractures
Life Sciences
Melanin
Original Research
Orthopedics
Photosensitivity
Pigmentation
Questionnaires
Radioimmunoassay
Skin
Skin cancer
Spectrophotometry
Spine (lumbar)
Sunburn & sun tanning
Vitamin D
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Summary:Whether skin photosensitivity modulates sun exposure behaviours, consequent vitamin D status and skeletal health outcomes independently of constitutive pigmentation have not been systematically investigated. 1072 community-dwelling adults aged 50–80 years had skin photosensitivity quantified by questionnaire and melanin density by spectrophotometry. Bone mineral density (BMD), falls risk and 25-hydroxyvitamin D (25OHD) were measured using DXA, short form physiological profile assessment and radioimmunoassay, respectively. Sun exposure and symptomatic fractures were assessed by questionnaire. Participants were followed up at 2.5 ( n  = 879), 5 ( n  = 767) and 10 ( n  = 571) years. Higher resistance to sunburn and greater ability to tan were associated with reduced sun protection behaviours (RR 0.87, p  
ISSN:0171-967X
1432-0827
DOI:10.1007/s00223-020-00728-w