Evaluation Of Camellia sinensis, Withania somnifera and their Combination for Antioxidant and Antiparkinsonian Effect

• Published in: Journal of pharmaceutical sciences and research 2020-08, Vol.12 (8), p.1093-1099
• Main Authors: Giri, M A, Bhalke, R D, Prakash, K VANITHA, Kasture, S B
• Format: Article
• Language: English
• Subjects: Albinism; Animals; Antioxidants; Dopamine; Drug dosages; Dyskinesia; Experiments; Flavonoids; Parkinson's disease; Pharmaceutical sciences; Polyphenols; Rodents
• ISSN: 0975-1459

Keywords: Antioxidant, Antiparkinson, Camellia sinensis, Withania somnifers, Haloperidol, Reserpine, Tacrine Introduction: Neurodegenerative diseases like Alzheimer's, Parkinson's, Huntington's and multiple sclerosis are associated with the process of memory loss and cognitive decline which results from selective degeneration of particular neuronal cells and the deposit of aggregated proteins. Parkinson's disease (PD) is mainly characterized as a movement disorder but non-motor symptoms are also involved. Since dopamine is associated with motor activity, the progressive loss of dopaminergic neurons in PD leads to muscle rigidity, tremors and bradykinesia as well as cognition, mental, sleeping, personality and behaviour disorders including depression and anxiety [1-2]. Levodopa has been considered the gold standard drug therapy for Parkinson's disease but it is limited only to relieving symptoms and its long term use may cause serious side effects that include involuntary movements (dyskinesia), the on-off effect may cause Parkinson's related movement problems to appear and disappear suddenly and unpredictably. Institutional Animal Ethics Committee for Animal Experiments of Sanjivani College of Pharmaceutical Education and Research, Kopargaon, approved the study under the protocol SCPER/CPCSEA/IAEC/2019-20/01 and all experiments were conducted in accordance with guidelines of Committee for the Purpose of Control and Supervision of Experiments on Animals (CPCSEA).