Boron-doped diamond electrode as efficient sensing platform for simultaneous quantification of mefenamic acid and indomethacin

Mefenamic acid and indomethacin, medicaments belonging to the group of non-steroidal anti-inflammatory agents, were determined separately and simultaneously at anodically prepared BDDE. Differential pulse voltammetry was used to establish simple and fast analytical procedure based on electrooxidatio...

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Bibliographic Details
Published in:Diamond and related materials 2020-05, Vol.105, p.107785, Article 107785
Main Authors: Petković, Branka B., Ognjanović, Miloš, Krstić, Milena, Stanković, Vesna, Babincev, Ljiljana, Pergal, Marija, Stanković, Dalibor M.
Format: Article
Language:English
Subjects:
Acids
Anti-inflammatory drug analysis
Boron
Chemical sensors
Diamonds
Electrodes
Formulations
Indomethacin
Mefenamic acid
Nonsteroidal anti-inflammatory drugs
Selectivity
Unmodified BDDE
Vitamins
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Summary:Mefenamic acid and indomethacin, medicaments belonging to the group of non-steroidal anti-inflammatory agents, were determined separately and simultaneously at anodically prepared BDDE. Differential pulse voltammetry was used to establish simple and fast analytical procedure based on electrooxidation of mefenamic acid at 0.6 V and indomethacin at 1.0 V (and 1.1 V). At optimal conditions, it was suitable for highly sensitive and selective determination of these compounds with LODs comparable to previously reported modified electrodes. Additionally, considering the importance of these compounds, we proposed precise and accurate quantification of these species based on green and simple pre-treatable electrochemical sensor. The effect of interfering agents (tablet ingredients and vitamins) was appeared to be negligibly confirming a favourable selectivity of the method. The proposed method was analytically applied by simultaneously determining mefenamic acid and indomethacin in pharmaceutical formulations. [Display omitted] •Separate and simultaneous DPV determination of mefenamic acid and indomethacin at BDDE•Efficient procedure with simple electrochemical pretreatment at unmodified electrode•Applied for highly selective analysis of those compounds from pharmaceutical products
ISSN:0925-9635
1879-0062
DOI:10.1016/j.diamond.2020.107785