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Novel 2‐hydroxynaphthalene‐based fluorescent turn‐on sensor for highly sensitive and selective detection of Al3+ and its application in imaging in vitro and in vivo
Excessive aluminum exposure in the human body has been held responsible for multiple adverse effects, and existing data underscore the significance of aluminum detection in environmental and biological systems. Developing high‐performance Al3+ fluorescent chemosensors can revolutionize our understan...
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Published in: | Applied organometallic chemistry 2020-10, Vol.34 (10), p.n/a |
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creator | Xu, Ling‐Wen Wang, Xin‐Tian Zou, Yun‐Hong Yu, Xu‐Ya Xie, Cheng‐Zhi Qiao, Xin Li, Qing‐Zhong Xu, Jing‐Yuan |
description | Excessive aluminum exposure in the human body has been held responsible for multiple adverse effects, and existing data underscore the significance of aluminum detection in environmental and biological systems. Developing high‐performance Al3+ fluorescent chemosensors can revolutionize our understanding of the physiological and pathological processes of Al3+ ions. Herein, we reported a highly sensitive and selective Schiff base fluorescence sensor, bis‐NAPPD (1,1'‐((1E,1'E)‐(pyridine‐2,3‐diylbis(azanylylidene))bis(methanylylidene))bis(naphthalen‐2‐ol)), which can recognize Al3+ ions and exhibits a remarkable turn‐on dual emission response (by ~23 fold) with a low nanomolar level detection limit (1.67 × 10−8 M) in methanol. Furthermore, the binding behavior and the turn‐on fluorescence probing mechanism of bis‐NAPPD were illustrated in detail by UV–vis titration, 1H NMR, and ESI‐MS spectroscopy as well as density functional theory calculations. Notably, bis‐NAPPD showed great potential for tracing Al3+ distribution in cells and living zebrafish larvae, and can also be applied in the fluorimetric detection of aluminum in sucralfate tablets with good precision and satisfactory accuracy, which may represent a promising Al3+ probe in bioimaging and biomedical applications.
Bis‐NAPPD showed great potential for tracing Al3+ distribution in cells and living zebrafish larvae, and can also be applied in the fluorimetric detection of aluminum in sucralfate tablets with good precision and satisfactory accuracy, which may represent a promising Al3+ probe in bioimaging and biomedical applications. |
doi_str_mv | 10.1002/aoc.5812 |
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Bis‐NAPPD showed great potential for tracing Al3+ distribution in cells and living zebrafish larvae, and can also be applied in the fluorimetric detection of aluminum in sucralfate tablets with good precision and satisfactory accuracy, which may represent a promising Al3+ probe in bioimaging and biomedical applications.</description><identifier>ISSN: 0268-2605</identifier><identifier>EISSN: 1099-0739</identifier><identifier>DOI: 10.1002/aoc.5812</identifier><language>eng</language><publisher>Chichester: Wiley Subscription Services, Inc</publisher><subject>Aluminum ; biological imaging ; Biomedical materials ; Chemical sensors ; Chemistry ; Chemoreceptors ; Density functional theory ; Fluorescence ; fluorescent probe ; Imines ; Larvae ; Medical imaging ; NMR ; Nuclear magnetic resonance ; Schiff base ; Titration ; Zebrafish</subject><ispartof>Applied organometallic chemistry, 2020-10, Vol.34 (10), p.n/a</ispartof><rights>2020 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-1660-412X ; 0000-0002-9544-0193</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids></links><search><creatorcontrib>Xu, Ling‐Wen</creatorcontrib><creatorcontrib>Wang, Xin‐Tian</creatorcontrib><creatorcontrib>Zou, Yun‐Hong</creatorcontrib><creatorcontrib>Yu, Xu‐Ya</creatorcontrib><creatorcontrib>Xie, Cheng‐Zhi</creatorcontrib><creatorcontrib>Qiao, Xin</creatorcontrib><creatorcontrib>Li, Qing‐Zhong</creatorcontrib><creatorcontrib>Xu, Jing‐Yuan</creatorcontrib><title>Novel 2‐hydroxynaphthalene‐based fluorescent turn‐on sensor for highly sensitive and selective detection of Al3+ and its application in imaging in vitro and in vivo</title><title>Applied organometallic chemistry</title><description>Excessive aluminum exposure in the human body has been held responsible for multiple adverse effects, and existing data underscore the significance of aluminum detection in environmental and biological systems. Developing high‐performance Al3+ fluorescent chemosensors can revolutionize our understanding of the physiological and pathological processes of Al3+ ions. Herein, we reported a highly sensitive and selective Schiff base fluorescence sensor, bis‐NAPPD (1,1'‐((1E,1'E)‐(pyridine‐2,3‐diylbis(azanylylidene))bis(methanylylidene))bis(naphthalen‐2‐ol)), which can recognize Al3+ ions and exhibits a remarkable turn‐on dual emission response (by ~23 fold) with a low nanomolar level detection limit (1.67 × 10−8 M) in methanol. Furthermore, the binding behavior and the turn‐on fluorescence probing mechanism of bis‐NAPPD were illustrated in detail by UV–vis titration, 1H NMR, and ESI‐MS spectroscopy as well as density functional theory calculations. Notably, bis‐NAPPD showed great potential for tracing Al3+ distribution in cells and living zebrafish larvae, and can also be applied in the fluorimetric detection of aluminum in sucralfate tablets with good precision and satisfactory accuracy, which may represent a promising Al3+ probe in bioimaging and biomedical applications.
Bis‐NAPPD showed great potential for tracing Al3+ distribution in cells and living zebrafish larvae, and can also be applied in the fluorimetric detection of aluminum in sucralfate tablets with good precision and satisfactory accuracy, which may represent a promising Al3+ probe in bioimaging and biomedical applications.</description><subject>Aluminum</subject><subject>biological imaging</subject><subject>Biomedical materials</subject><subject>Chemical sensors</subject><subject>Chemistry</subject><subject>Chemoreceptors</subject><subject>Density functional theory</subject><subject>Fluorescence</subject><subject>fluorescent probe</subject><subject>Imines</subject><subject>Larvae</subject><subject>Medical imaging</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Schiff base</subject><subject>Titration</subject><subject>Zebrafish</subject><issn>0268-2605</issn><issn>1099-0739</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNotUUtOwzAQtRBIlILEESKxRCljx4njZVXxkyq6gXXkOnZiZOIQp4HsOALn4FicBKdF8mjmzXv2ePQQusSwwADkRji5SHNMjtAMA-cxsIQfoxmQLI9JBukpOvP-FQB4hukM_Ty5QdmI_H5912PZuc-xEW3d18KqRoXmVnhVRtruXKe8VE0f9buuCYRrIq8a77pIh6hNVdtx3zG9GVQkmjIgq-QelaqfqnDH6Whpk-s9b3ofiba1Roo9Z8J5E5VpqqkcTN-5g24CgztHJ1pYry7-8xy93N0-rx7i9eb-cbVcxxXOcxJjqsJunCVMp1upU8E4zYXmCktJBSk1JQxoKnHCFUhKOaaaMcCM5VvIQCdzdHV4t-3c-075vnh1YecwsiCUEiApzyGo4oPqw1g1Fm0Xvt6NBYZisqEINhSTDcVys5py8ge-d4HK</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Xu, Ling‐Wen</creator><creator>Wang, Xin‐Tian</creator><creator>Zou, Yun‐Hong</creator><creator>Yu, Xu‐Ya</creator><creator>Xie, Cheng‐Zhi</creator><creator>Qiao, Xin</creator><creator>Li, Qing‐Zhong</creator><creator>Xu, Jing‐Yuan</creator><general>Wiley Subscription Services, Inc</general><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope><orcidid>https://orcid.org/0000-0002-1660-412X</orcidid><orcidid>https://orcid.org/0000-0002-9544-0193</orcidid></search><sort><creationdate>202010</creationdate><title>Novel 2‐hydroxynaphthalene‐based fluorescent turn‐on sensor for highly sensitive and selective detection of Al3+ and its application in imaging in vitro and in vivo</title><author>Xu, Ling‐Wen ; Wang, Xin‐Tian ; Zou, Yun‐Hong ; Yu, Xu‐Ya ; Xie, Cheng‐Zhi ; Qiao, Xin ; Li, Qing‐Zhong ; Xu, Jing‐Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g1882-14e0969737f5bcf5a7948af9e1cc4a2df427045c139e0c44914f7701778b060f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aluminum</topic><topic>biological imaging</topic><topic>Biomedical materials</topic><topic>Chemical sensors</topic><topic>Chemistry</topic><topic>Chemoreceptors</topic><topic>Density functional theory</topic><topic>Fluorescence</topic><topic>fluorescent probe</topic><topic>Imines</topic><topic>Larvae</topic><topic>Medical imaging</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Schiff base</topic><topic>Titration</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Ling‐Wen</creatorcontrib><creatorcontrib>Wang, Xin‐Tian</creatorcontrib><creatorcontrib>Zou, Yun‐Hong</creatorcontrib><creatorcontrib>Yu, Xu‐Ya</creatorcontrib><creatorcontrib>Xie, Cheng‐Zhi</creatorcontrib><creatorcontrib>Qiao, Xin</creatorcontrib><creatorcontrib>Li, Qing‐Zhong</creatorcontrib><creatorcontrib>Xu, Jing‐Yuan</creatorcontrib><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Applied organometallic chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Ling‐Wen</au><au>Wang, Xin‐Tian</au><au>Zou, Yun‐Hong</au><au>Yu, Xu‐Ya</au><au>Xie, Cheng‐Zhi</au><au>Qiao, Xin</au><au>Li, Qing‐Zhong</au><au>Xu, Jing‐Yuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel 2‐hydroxynaphthalene‐based fluorescent turn‐on sensor for highly sensitive and selective detection of Al3+ and its application in imaging in vitro and in vivo</atitle><jtitle>Applied organometallic chemistry</jtitle><date>2020-10</date><risdate>2020</risdate><volume>34</volume><issue>10</issue><epage>n/a</epage><issn>0268-2605</issn><eissn>1099-0739</eissn><abstract>Excessive aluminum exposure in the human body has been held responsible for multiple adverse effects, and existing data underscore the significance of aluminum detection in environmental and biological systems. Developing high‐performance Al3+ fluorescent chemosensors can revolutionize our understanding of the physiological and pathological processes of Al3+ ions. Herein, we reported a highly sensitive and selective Schiff base fluorescence sensor, bis‐NAPPD (1,1'‐((1E,1'E)‐(pyridine‐2,3‐diylbis(azanylylidene))bis(methanylylidene))bis(naphthalen‐2‐ol)), which can recognize Al3+ ions and exhibits a remarkable turn‐on dual emission response (by ~23 fold) with a low nanomolar level detection limit (1.67 × 10−8 M) in methanol. Furthermore, the binding behavior and the turn‐on fluorescence probing mechanism of bis‐NAPPD were illustrated in detail by UV–vis titration, 1H NMR, and ESI‐MS spectroscopy as well as density functional theory calculations. Notably, bis‐NAPPD showed great potential for tracing Al3+ distribution in cells and living zebrafish larvae, and can also be applied in the fluorimetric detection of aluminum in sucralfate tablets with good precision and satisfactory accuracy, which may represent a promising Al3+ probe in bioimaging and biomedical applications.
Bis‐NAPPD showed great potential for tracing Al3+ distribution in cells and living zebrafish larvae, and can also be applied in the fluorimetric detection of aluminum in sucralfate tablets with good precision and satisfactory accuracy, which may represent a promising Al3+ probe in bioimaging and biomedical applications.</abstract><cop>Chichester</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/aoc.5812</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0002-1660-412X</orcidid><orcidid>https://orcid.org/0000-0002-9544-0193</orcidid></addata></record> |
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subjects | Aluminum biological imaging Biomedical materials Chemical sensors Chemistry Chemoreceptors Density functional theory Fluorescence fluorescent probe Imines Larvae Medical imaging NMR Nuclear magnetic resonance Schiff base Titration Zebrafish |
title | Novel 2‐hydroxynaphthalene‐based fluorescent turn‐on sensor for highly sensitive and selective detection of Al3+ and its application in imaging in vitro and in vivo |
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