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Novel 2‐hydroxynaphthalene‐based fluorescent turn‐on sensor for highly sensitive and selective detection of Al3+ and its application in imaging in vitro and in vivo

Excessive aluminum exposure in the human body has been held responsible for multiple adverse effects, and existing data underscore the significance of aluminum detection in environmental and biological systems. Developing high‐performance Al3+ fluorescent chemosensors can revolutionize our understan...

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Published in:Applied organometallic chemistry 2020-10, Vol.34 (10), p.n/a
Main Authors: Xu, Ling‐Wen, Wang, Xin‐Tian, Zou, Yun‐Hong, Yu, Xu‐Ya, Xie, Cheng‐Zhi, Qiao, Xin, Li, Qing‐Zhong, Xu, Jing‐Yuan
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container_title Applied organometallic chemistry
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creator Xu, Ling‐Wen
Wang, Xin‐Tian
Zou, Yun‐Hong
Yu, Xu‐Ya
Xie, Cheng‐Zhi
Qiao, Xin
Li, Qing‐Zhong
Xu, Jing‐Yuan
description Excessive aluminum exposure in the human body has been held responsible for multiple adverse effects, and existing data underscore the significance of aluminum detection in environmental and biological systems. Developing high‐performance Al3+ fluorescent chemosensors can revolutionize our understanding of the physiological and pathological processes of Al3+ ions. Herein, we reported a highly sensitive and selective Schiff base fluorescence sensor, bis‐NAPPD (1,1'‐((1E,1'E)‐(pyridine‐2,3‐diylbis(azanylylidene))bis(methanylylidene))bis(naphthalen‐2‐ol)), which can recognize Al3+ ions and exhibits a remarkable turn‐on dual emission response (by ~23 fold) with a low nanomolar level detection limit (1.67 × 10−8 M) in methanol. Furthermore, the binding behavior and the turn‐on fluorescence probing mechanism of bis‐NAPPD were illustrated in detail by UV–vis titration, 1H NMR, and ESI‐MS spectroscopy as well as density functional theory calculations. Notably, bis‐NAPPD showed great potential for tracing Al3+ distribution in cells and living zebrafish larvae, and can also be applied in the fluorimetric detection of aluminum in sucralfate tablets with good precision and satisfactory accuracy, which may represent a promising Al3+ probe in bioimaging and biomedical applications. Bis‐NAPPD showed great potential for tracing Al3+ distribution in cells and living zebrafish larvae, and can also be applied in the fluorimetric detection of aluminum in sucralfate tablets with good precision and satisfactory accuracy, which may represent a promising Al3+ probe in bioimaging and biomedical applications.
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subjects Aluminum
biological imaging
Biomedical materials
Chemical sensors
Chemistry
Chemoreceptors
Density functional theory
Fluorescence
fluorescent probe
Imines
Larvae
Medical imaging
NMR
Nuclear magnetic resonance
Schiff base
Titration
Zebrafish
title Novel 2‐hydroxynaphthalene‐based fluorescent turn‐on sensor for highly sensitive and selective detection of Al3+ and its application in imaging in vitro and in vivo
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