Meningitis and bacteremia by nonhemolytic Group B Streptococcus strain: A whole genome analysis

Group B streptococcus (GBS) is a leading cause of neonatal infections. Most isolates are β‐hemolytic, and their activity is considered to be pivotal for GBS pathogenicity. We report a case of a neonate with meningitis caused by nonhemolytic GBS. The patient developed meningitis 3 days after birth. G...

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Bibliographic Details
Published in:Microbiology and immunology 2020-09, Vol.64 (9), p.630-634
Main Authors: Shimizu, Akihiko, Tsukagoshi, Hiroyuki, Sekizuka, Tsuyoshi, Kuroda, Makoto, Koizumi, Aya, Fujita, Masahiro, Yamada, Yoshiyuki, Saruki, Nobuhiro
Format: Article
Language:English
Subjects:
Bacteremia
Case reports
Child, Preschool
cylA
Frameshift mutation
Genome, Bacterial
Genomes
Genotyping
Hemolysin Proteins - genetics
Humans
Insertion
Male
Meningitis
Meningitis, Bacterial - diagnosis
Meningitis, Bacterial - microbiology
Neonates
Next-generation sequencing
nonhemolytic strain
Nucleotide sequence
Pathogenicity
Phylogeny
Streptococcal Infections - diagnosis
Streptococcal Infections - microbiology
Streptococcus
Streptococcus agalactiae
Streptococcus agalactiae - classification
Streptococcus agalactiae - genetics
Streptococcus agalactiae - isolation & purification
Streptococcus infections
Virulence Factors - genetics
Whole Genome Sequencing
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Summary:Group B streptococcus (GBS) is a leading cause of neonatal infections. Most isolates are β‐hemolytic, and their activity is considered to be pivotal for GBS pathogenicity. We report a case of a neonate with meningitis caused by nonhemolytic GBS. The patient developed meningitis 3 days after birth. Genotyping was performed and the characteristics of the strain (GCMC97051) identified by whole genome sequence using next generation sequencing. GCMC97051 possesses genetic alterations such as disruption of cylA by IS1381A insertion and a frameshift mutation in cylE, resulting in a lack of hemolysis. Thus, nonhemolytic GBS can retain the potential to cause invasive infections.
ISSN:0385-5600
1348-0421
DOI:10.1111/1348-0421.12826