Role of aromatic amino acids in pathogeneses of diabetic nephropathy in Chinese patients with type 2 diabetes

We aimed to estimate the associations between aromatic amino acids (AAAs) and diabetic nephropathy (DN) in patients with type 2 diabetes (T2D). We collected clinical and metabolomic data from 132 healthy subjects (HS group), 132 type 2 diabetes patients without diabetic nephropathy (T2D group) and 1...

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Published in:Journal of diabetes and its complications 2020-10, Vol.34 (10), p.107667, Article 107667
Main Authors: Zhang, Shiti, Li, Xin, Luo, Huihuan, Fang, Zhong-Ze, Ai, Hao
Format: Article
Language:English
Subjects:
Age
Amino acids
Aromatic amino acids
Beta blockers
Blood pressure
Body mass index
Cholesterol
Diabetes
Diabetic nephropathy
Enzymes
Hospitals
Insulin
Kidney diseases
Laboratories
Lipoproteins
Metabolites
Normal distribution
Phenylalanine
Statistical analysis
Tryptophan
Tyrosine
Variance analysis
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Summary:We aimed to estimate the associations between aromatic amino acids (AAAs) and diabetic nephropathy (DN) in patients with type 2 diabetes (T2D). We collected clinical and metabolomic data from 132 healthy subjects (HS group), 132 type 2 diabetes patients without diabetic nephropathy (T2D group) and 132 diabetic nephropathy patients (DN group) in tertiary hospital from May 2015 to August 2016. The odds ratio (OR) and 95% confidence interval (CI) were obtained by logistic regression. The odds ratio of tyrosine for DN increased gradually. High tyrosine was associated with an increased OR of DN (model 3, OR:0.329, 95%CI, 0.144–0.750) when comparing extreme quantiles. In Chinese patients with T2D, elevated tyrosine was associated with increased risk of DN. •Elevated phenylalanine, tryptophan and tyrosine were associated with decreased diabetic nephropathy risk.•Aromatic amino acids have the potential of the diagnosis of diabetic nephropathy.•Aromatic amino acids appear to associate with the pathogenesis of diabetic nephropathy.
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2020.107667