Fetal growth and well‐being in a study of maternal hypertension in rabbits

Obtaining growth and physiologic data in the postnatal laboratory animal is common. However, monitoring growth in utero is far more difficult, with little data available except upon termination of pregnancy. High‐resolution ultrasound was used to monitor growth, morphology, and fetal well‐being in n...

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Bibliographic Details
Published in:Anatomical record (Hoboken, N.J. : 2007) N.J. : 2007), 2020-10, Vol.303 (10), p.2646-2656
Main Authors: Coombs, Peter, Walton, Sarah L., Maduwegedera, Devaki, Flower, Rebecca L., Denton, Kate M.
Format: Article
Language:English
Subjects:
Animals
Biometry
Birth weight
Birth Weight - physiology
development
Female
Fetal Development - physiology
fetal programming
fetus
Fetuses
Gestation
Gestational Age
Hypertension
hypertension in pregnancy
Hypertension, Pregnancy-Induced - diagnostic imaging
Hypertension, Pregnancy-Induced - physiopathology
Laboratory animals
Offspring
Pregnancy
rabbit
Rabbits
Ultrasonic imaging
Ultrasonography
Ultrasound
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Summary:Obtaining growth and physiologic data in the postnatal laboratory animal is common. However, monitoring growth in utero is far more difficult, with little data available except upon termination of pregnancy. High‐resolution ultrasound was used to monitor growth, morphology, and fetal well‐being in normotensive and hypertensive rabbits (21 fetuses) at day 16, 20, and 26 of the 32 day gestational period. Set protocols, comparable to those routinely assessed in humans, were devised and followed for each examination. Birth weight was greater in offspring of hypertensive as compared to normotensive mothers (p 
ISSN:1932-8486
1932-8494
DOI:10.1002/ar.24344