Structuring hydrophobic domains in Poly(N-isopropylacrylamide-co-Methacrylic acid) hydrogels

[Display omitted] •PNIPAM-MAA hydrogel was structured with hydrophobic compartments.•Structured hydrogel was able to load hydrophobic molecules as well as charged drugs.•This hydrogel permitted the cell adhesion and growth and the detachment when T‹LCST. Poly(N-isopropylacrylamide-co-methacrylic aci...

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Bibliographic Details
Published in:European polymer journal 2020-05, Vol.131, p.109695, Article 109695
Main Authors: López-González, Mar, Melia Rodrigo, M., Valiente, Mercedes, Trabado, Isabel, Mendicuti, Francisco, Marcelo, Gema
Format: Article
Language:English
Subjects:
Cell adhesion
Cell adhesion & migration
Compartments
Copolymerization
Domains
Doxorubicin
Hydrogels
Hydrophobic surfaces
Hydrophobicity
Isopropylacrylamide
Methacrylamide
Methacrylic acid
Polymers
Sodium
Sodium dodecyl sulfate
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Summary:[Display omitted] •PNIPAM-MAA hydrogel was structured with hydrophobic compartments.•Structured hydrogel was able to load hydrophobic molecules as well as charged drugs.•This hydrogel permitted the cell adhesion and growth and the detachment when T‹LCST. Poly(N-isopropylacrylamide-co-methacrylic acid) hydrogels were structured with hydrophobic compartments. To achieve that, N-isopropylacrylamide was copolymerized with methacrylic acid and a small percentage (~0.4 %mol) of (3,4-dihydroxy-5-nitrophenyl)methacrylamide (nitrocatechol monomer) in the presence of sodium dodecyl sulphate at a concentration below its CMC value. All the results support the structuring of poly(N-isopropylacrylamide-co-methacrylic acid) hydrogels with hydrophobic domains in water. These compartments were found to be rich in methacrylic acid and nitrocatechol units. Moreover, the structuring disappeared when hydrogels were swollen at pH 7.4. The structured hydrogel was capable of loading hydrophobic molecules (methyl-2-naphthoate and methyl-9-anthracenecarboxylate) as well as charged drugs (doxorubicin hydrochloride). This hydrogel permitted cell adhesion and growth as well as its detachment when the temperature fell below the LCST.
ISSN:0014-3057
1873-1945
DOI:10.1016/j.eurpolymj.2020.109695