A biostable, anti-fouling zwitterionic polyurethane-urea based on PDMS for use in blood-contacting medical devices

• Published in: Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2020-09, Vol.8 (36), p.835-8314
• Main Authors: Kim, Seungil, Ye, Sang-ho, Adamo, Arianna, Orizondo, Ryan A, Jo, Jaehyuk, Cho, Sung Kwon, Wagner, William R
• Format: Article
• Language: English
• Subjects: Adsorption; Animals; Antifouling substances; Biocompatibility; Biofouling - prevention & control; Biomaterials; Biomedical materials; Blood; Blood Platelets - drug effects; Chemical synthesis; Coated Materials, Biocompatible - chemical synthesis; Coated Materials, Biocompatible - chemistry; Coated Materials, Biocompatible - toxicity; Crosslinking; Cytotoxicity; Dimethylpolysiloxanes - chemical synthesis; Dimethylpolysiloxanes - chemistry; Dimethylpolysiloxanes - toxicity; Electronic devices; Fabrication; Fibrinogen; Fibrinogen - chemistry; Fibrinogen - metabolism; Hemolysis - drug effects; Hydrogen peroxide; Lipase; Magnetic properties; Medical equipment; Microfluidic devices; Microfluidics; Muscles; NMR; Nuclear magnetic resonance; Oxidative stress; Physical properties; Platelet Adhesiveness - drug effects; Platelets; Polydimethylsiloxane; Polypropylene; Polyurethane; Polyurethane resins; Polyurethanes - chemical synthesis; Polyurethanes - chemistry; Polyurethanes - toxicity; Polyurethaneureas; Quaternary Ammonium Compounds - chemical synthesis; Quaternary Ammonium Compounds - chemistry; Quaternary Ammonium Compounds - toxicity; Rats; Sheep; Silicon; Smooth muscle; Sulfonic Acids - chemical synthesis; Sulfonic Acids - chemistry; Sulfonic Acids - toxicity; Toxicity; Urea; Ureas; X-ray diffraction; Zwitterions
• ISSN: 2050-750X; 2050-7518
• DOI: 10.1039/d0tb01220c

Polydimethylsiloxane (PDMS) is commonly used in medical devices because it is non-toxic and stable against oxidative stress. Relatively high blood platelet adhesion and the need for chemical crosslinking through curing, however, limit its utility. In this research, a biostable PDMS-based polyurethane-urea bearing zwitterion sulfobetaine ( PDMS-SB-UU ) was synthesized for potential use in the fabrication or coating of blood-contacting devices, such as a conduits, artificial lungs, and microfluidic devices. The chemical structure and physical properties of synthesized PDMS-SB-UU were confirmed by 1 H-nuclear magnetic resonance ( 1 H-NMR), X-ray diffraction (XRD), and uniaxial stress-strain curve. In vitro stability of PDMS-SB-UU was confirmed against lipase and 30% H 2 O 2 for 8 weeks, and PDMS-SB-UU demonstrated significantly higher resistance to fibrinogen adsorption and platelet deposition compared to control PDMS. Moreover, PDMS-SB-UU showed a lack of hemolysis and cytotoxicity with whole ovine blood and rat vascular smooth muscle cells (rSMCs), respectively. The PDMS-SB-UU was successfully processed into small-diameter (0.80 ± 0.05 mm) conduits by electrospinning and coated onto PDMS- and polypropylene-based blood-contacting biomaterials due to its unique physicochemical characteristics from its soft- and hard- segments. Development and processing of a biostable, anti-fouling zwitterionic polyurethane-urea based on PDMS for blood-contacting medical devices.