Molecular Engineering to Boost AIE‐Active Free Radical Photogenerators and Enable High‐Performance Photodynamic Therapy under Hypoxia

• Published in: Advanced functional materials 2020-09, Vol.30 (39), p.n/a
• Main Authors: Wan, Qing, Zhang, Rongyuan, Zhuang, Zeyan, Li, Yuxuan, Huang, Yuhua, Wang, Zhiming, Zhang, Weijie, Hou, Jianquan, Tang, Ben Zhong
• Format: Article
• Language: English
• Subjects: Agglomeration; aggregation‐induced emission; Charge transfer; Fluorescence; free radical reactive oxygen species; Free radicals; Hypoxia; hypoxia tumor treatment; Infrared imaging; Internal conversion; Materials science; molecular engineering; Photodynamic therapy; Tumors
• ISSN: 1616-301X; 1616-3028
• DOI: 10.1002/adfm.202002057

The severe hypoxia in solid tumors and the vicious aggregation‐caused fluorescence quenching (ACQ) of conventional photosensitizers (PSs) have limited the application of fluorescence imaging‐guided photodynamic therapy (PDT), although this therapy has obvious advantages in terms of its precise spatial–temporal control and noninvasive character. PSs featuring type I reactive oxygen species (ROS) based on free radicals and novel aggregation‐induced emission (AIE) characteristics (AIE‐PSs) could offer valuable opportunities to resolve the above problems, but molecular engineering methods are rare in previous reports. Herein, a strategy is proposed for generating stronger intramolecular charge transfer in electron‐rich anion‐π+ AIE‐active luminogens (AIEgens) to help suppress nonradiative internal conversion and to promote radiative and intersystem crossing to boost free radical generation. Systematic and detailed experimental and theoretical calculations prove the proposal herein: the electron‐donating abilities are enhanced in collaborative donors, and the AIE‐PSs exhibit higher performance in near‐infrared fluorescence imaging‐guided cancer PDT in vitro/vivo. This work serves as an important reference for the design of AIE‐active free radical generators to overcome the ACQ and tumor hypoxia challenges in PDT. A feasible molecular engineering method is proposed for achieving the transformation of AIE‐active type I free radical ROS generators from type II 1O2 species to overcome ACQ effect and enable high‐performance photodynamic theory under hypoxia.