Safe administration of high‐dose methotrexate with minimal drug level monitoring: Experience from a center in north India

Background High‐dose methotrexate (HDMTX) is recommended to be administered with serial monitoring of methotrexate (MTX) levels, which may not be universally feasible in resource‐limited settings. In this study, we evaluated the overall experience of administration of HDMTX at our center by monitori...

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Bibliographic Details
Published in:Pediatric blood & cancer 2020-11, Vol.67 (11), p.e28394-n/a
Main Authors: Dhingra, Himani, Kalra, Manas, Mahajan, Amita
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Adolescent
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Child
Child, Preschool
Dose-Response Relationship, Drug
Drug dosages
drug levels
Drug Monitoring - methods
Female
Follow-Up Studies
Hematology
high‐dose methotrexate
Humans
India
Infant
Leucovorin - administration & dosage
leucovorin rescue
Lymphatic leukemia
Lymphoma, Non-Hodgkin - blood
Lymphoma, Non-Hodgkin - drug therapy
Lymphoma, Non-Hodgkin - pathology
Male
Medical records
Methotrexate
Methotrexate - administration & dosage
methotrexate toxicity
Non-Hodgkin's lymphoma
Oncology
Patients
Pediatrics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Prognosis
Retrospective Studies
Survival Rate
Toxicity
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Summary:Background High‐dose methotrexate (HDMTX) is recommended to be administered with serial monitoring of methotrexate (MTX) levels, which may not be universally feasible in resource‐limited settings. In this study, we evaluated the overall experience of administration of HDMTX at our center by monitoring a single drug level at 54 h from the start of MTX infusion. Methods This retrospective study was performed at a tertiary level hospital in north India, over a 5‐year period (2011‐2015). All patients
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.28394