Metal-organic framework based nanozymes: promising materials for biochemical analysis

In recent years, there has been rapid growth of enzyme-mimicking catalytic nanomaterials (nanozymes). Compared with biological enzymes, nanozymes exhibit several superiorities, including robust activity, easy production, and low cost, which endow them with promising applications in biochemical analy...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-09, Vol.56 (77), p.11338-11353
Main Authors: Niu, Xiangheng, Li, Xin, Lyu, Zhaoyuan, Pan, Jianming, Ding, Shichao, Ruan, Xiaofan, Zhu, Wenlei, Du, Dan, Lin, Yuehe
Format: Article
Language:English
Subjects:
Biochemistry
Biomimetic Materials - chemistry
Catalysis
Cost analysis
Enzymes
Metal-organic frameworks
Metal-Organic Frameworks - chemistry
Molecular Structure
Nanomaterials
Nanostructures - chemistry
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Summary:In recent years, there has been rapid growth of enzyme-mimicking catalytic nanomaterials (nanozymes). Compared with biological enzymes, nanozymes exhibit several superiorities, including robust activity, easy production, and low cost, which endow them with promising applications in biochemical analysis. As an emerging member of nanozymes, metal-organic framework (MOF) nanozymes are attracting growing attention because of their composition and structural characteristics. Rationally designing MOFs with enzyme-like catalytic ability is opening up a new avenue for biochemical detection. In this Feature Article, we summarize the latest developments of MOF nanozymes and their applications in biochemical sensing. First, the types of nanozymes derived from MOFs are categorized, and effective strategies to improve the weak activity inherent in MOF nanozymes are introduced. Then, the multi-functionalization of MOFs with enzyme mimic activity and other attractive properties is emphasized. After that, the typical applications of MOF nanozymes in the detection of various analytes are rigorously reviewed. Finally, the current challenges and some development directions in this field are discussed. It is believed that the versatile nature of MOFs will bring a bright future for MOF nanozymes in biochemical analysis. Metal-organic frameworks with enzyme-like catalytic features (MOF nanozymes) exhibit great promise in detecting various analytes with amplified signal outputs.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc04890a