INDUCTION OF VASODILATION BY HYDRO- GEN PEROXIDE AND ITS APPLICATION IN EXERCISE SCIENCE

Regular exercise or physical activity benefits the cardiovascular system, lowers mortality and morbidity, and is a particularly important factor for maintaining the health of blood vessels by improving the function of endothelial cells. Shear stress and increased metabolic rate caused by exercise in...

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Bibliographic Details
Published in:Biology of sport 2012-01, Vol.29 (2), p.87
Main Authors: Sung, D J, So, W Y, Ryu, H Y, An, H S, Cha, K S
Format: Article
Language:English
Subjects:
Blood pressure
Blood vessels
Calcium channels
Cardiovascular diseases
Cardiovascular system
Endothelial cells
Endothelium
Exercise
Hydrogen peroxide
Metabolic rate
Metabolism
Morbidity
Nitric oxide
Nitric-oxide synthase
Physical activity
Physical fitness
Physical training
Reactive oxygen species
Science
Smooth muscle
Vasodilation
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Summary:Regular exercise or physical activity benefits the cardiovascular system, lowers mortality and morbidity, and is a particularly important factor for maintaining the health of blood vessels by improving the function of endothelial cells. Shear stress and increased metabolic rate caused by exercise induce vasodilation by generating endothelium-derived relaxing factors (EDRF) such as nitric oxide. In addition, some studies suggest that vasodilation is also induced by endothelium-derived hyperpolarizing factors (EDHF) and substances such as H2O2. Thus, we undertook this study to show that reactive oxygen species such as H2O2 that have not previously been investigated in the field of exercise science may induce vasodilation and an increase in blood pressure, and to provide information for application in the field of exercise science. In this review, we discuss reports on H2O2 published in the fields of basic science and exercise science while focusing on vasodilation induced by H2O2. H2O2 induces vasodilation by simultaneously increasing endothelial NOS (eNOS) and directly activating the Ca2+- activated K+ channels of vascular smooth muscle cells. A novel study should be conducted in the field of H2O2 as a factor of vasodilation via increased metabolic rate during exercise.
ISSN:0860-021X
2083-1862
DOI:10.5604/20831862.988882