A new macrocyclic diterpenoid from Anisomeles indica

A new macrocyclic diterpenoid, 4β,5β-dihydroxyovatodiolide (1), together with twenty-two known compounds (2-23) were isolated from the MeOH extract of the dried aerial parts of Anisomeles indica (L.) O. Kuntze (Labiatae). The structure of 1 was established on the basis of spectral evidence. Phenylet...

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Bibliographic Details
Published in:Natural product research 2020-10, Vol.34 (19), p.2737-2745
Main Authors: Chao, Chen-Liang, Huang, Hui-Chi, Ding, Hsiou-Yu, Lai, Jenn-Haung, Lin, Hang-Ching, Chang, Wen-Liang
Format: Article
Language:English
Subjects:
12-O-Tetradecanoylphorbol-13-acetate
4β,5β-dihydroxyovatodiolide
Acetic acid
Anisomeles indica
anti-arthritis activity
CD28 antigen
Diterpenes
Interleukin 2
labiatae
Lymphocytes
Lymphocytes T
Monoclonal antibodies
Peripheral blood
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Summary:A new macrocyclic diterpenoid, 4β,5β-dihydroxyovatodiolide (1), together with twenty-two known compounds (2-23) were isolated from the MeOH extract of the dried aerial parts of Anisomeles indica (L.) O. Kuntze (Labiatae). The structure of 1 was established on the basis of spectral evidence. Phenylethanoids, acteoside (5) and isoacteoside (6) showed significant inhibitory to IL-2 secretion of with respect to phorbol myristate acetate and anti-CD28 monoclonal antibody co-stimulated activation of human peripheral blood T cells.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2019.1586692