Synthesis, characterization and antimicrobial properties of cyclotriphosphazenes bearing benzimidazolyl rings

[Display omitted] •Benzimidazolyl substituted cyclotriphosphazene derivatives were reported.•These derivatives were fully characterized by spectroscopic techniques.•Their antimicrobial properties were investigated.•Compound 7 has a potential to be used as an antimicrobial agent. In the present work,...

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Bibliographic Details
Published in:Inorganica Chimica Acta 2020-09, Vol.509, p.119679, Article 119679
Main Authors: İbişoğlu, Hanife, Erdemir, Eda, Atilla, Devrim, Şahin Ün, Şule, Topçu, Seray, Gül Şeker, Mine
Format: Article
Language:English
Subjects:
2,2′-dihydroxybiphenyl
Antiinfectives and antibacterials
Antimicrobial activity
Benzimidazole
Cyclotriphosphazene
E coli
NMR
Nuclear magnetic resonance
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Summary:[Display omitted] •Benzimidazolyl substituted cyclotriphosphazene derivatives were reported.•These derivatives were fully characterized by spectroscopic techniques.•Their antimicrobial properties were investigated.•Compound 7 has a potential to be used as an antimicrobial agent. In the present work, novel monospiro-(2′,2′′-dioxy-1′,1′′-biphenyl) cyclotriphosphazene derivatives containing benzimidazolyl moieties (5, 6 and 7) were synthesized and characterized by elemental analysis, mass and 1H- and 31P NMR spectroscopic techniques. The antimicrobial effects of these compounds were screened in vitro against Escherichia coli (ATCC 8739) as Gram-negative bacilli and Gram-positive strains Staphylococcus aureus (ATCC 29213) and Bacillus subtilis (ATCC 6633) as Gram(+) bacilli and Candida albicans (ATCC 10231) as fungi strains. In addition, compound 7 which was more effective substance than the other was evaluated by minimal inhibition concentration method.
ISSN:0020-1693
1873-3255
DOI:10.1016/j.ica.2020.119679