Biocompatibility and sustained drug release prolife of novel cocoa polyphenol varnish

• Main Authors: Pushpalatha, C., Hegde, Swaroop, Deveswaran, R.
• Format: Conference Proceeding
• Language: English
• Subjects: Biocompatibility; Catechin; Cocoa; Dental caries; Discoloration; Drug delivery systems; Fluoridation; Fluorides; Intervals; Toxicity
• ISSN: 0094-243X; 1551-7616
• DOI: 10.1063/5.0022710

Dental caries is a major health problem affecting both adults and children. Prevention of dental caries is a priority in dental services. Fluoride varnish is one of the known delivery system in the prevention of dental caries. But fluoride varnish is associated with certain drawbacks like dental fluorosis, discoloration of teeth, gingival burning sensation and development of contact allergy. Hence, a novel varnish containing isolated cocoa components like catechin and epicatechin was formulated which is natural and safe. The developed novel varnish was evaluated for biocompatibility and drug release profile. The biocompatibility of the developed varnish was evaluated using MTT (3-(4) 5-Dimethyl-thiazol-Zyl) - 2, 5 biphenyl tetrazolium bromide) assay at different dilutions (2.5%, 5%, 10% and 20%). The drug release profile of the formulation was evaluated using UV-Spectrometer at different time intervals (30mins, 1hr, 2hrs, 3hrs and 4hrs). The result shows that the developed varnish has excellent biocompatibility and sustained drug release from 30mins till 4hrs of time intervals. Based on the data, we can conclude that the developed dental varnish can be used clinically without any toxicity for prevention of dental caries.