Succinic acid: a novel and efficient organo-catalyst for synthesis of α-amino nitriles under solvent free condition

A simple, efficient and eco-friendly general protocol has been developed for the synthesis of three-component reaction methodology of Strecker’s α-amino nitriles by using various aldehyde or ketone, amines and trimethylsilyl cyanide (TMS-CN). In this methodology, succinic acid is used as a novel and...

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Bibliographic Details
Published in:Organic communications 2020-07, Vol.13 (3), p.103-113
Main Author: Ghogare, Ramesh
Format: Article
Language:English
Subjects:
Aldehydes
Amines
Catalysts
Chemical synthesis
Cyanides
Nitriles
Room temperature
Solvents
Succinic acid
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Summary:A simple, efficient and eco-friendly general protocol has been developed for the synthesis of three-component reaction methodology of Strecker’s α-amino nitriles by using various aldehyde or ketone, amines and trimethylsilyl cyanide (TMS-CN). In this methodology, succinic acid is used as a novel and efficient organo-catalyst in catalytic amount. This method was carried out under solvent free condition at room temperature for preparation of variety of α-amino nitriles derivatives in excellent yields. The present method provides significant advantages of organo-catalyst such as inexpensive, highly stable, environmentally benign and commercially available as well as solvent free reaction conditions and high conversions of the products with excellent yield.
ISSN:1307-6175
1307-6175
DOI:10.25135/acg.oc.81.20.08.1781