Production and Investigation of Radiopharmaceutical Nanoconstruction [212Pb]DOTATATE for Therapy of Malignant Neoplasms

A method for obtaining radiopharmaceutical nanoconstruction [ 212 Pb]DOTATATE for investigations in the field of neuroendocrine tumors therapy has been developed. A laboratory generator of β-emitting radionuclide 212 Pb with an operating efficiency of 40% has also been developed. To determine the cy...

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Bibliographic Details
Published in:Surface investigation, x-ray, synchrotron and neutron techniques x-ray, synchrotron and neutron techniques, 2020-10, Vol.14 (Suppl 1), p.S99-S104
Main Authors: Kokov, K., Demchenko, A., Egorova, B., Larkin, A., Lyundup, A., Makoveeva, K., Moiseeva, A., Panchenko, V., Proshin, M., Reshetov, I., Chuvilin, D.
Format: Article
Language:English
Subjects:
Chemistry and Materials Science
Materials Science
Neoplasms
Radiochemical analysis
Radioisotopes
Surfaces and Interfaces
Thin Films
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Summary:A method for obtaining radiopharmaceutical nanoconstruction [ 212 Pb]DOTATATE for investigations in the field of neuroendocrine tumors therapy has been developed. A laboratory generator of β-emitting radionuclide 212 Pb with an operating efficiency of 40% has also been developed. To determine the cytotoxic effect of the [ 212 Pb]DOTATATE complex, somatostatin receptor-expressing pancreatic cancer cells (Rin-m5F cell line) were incubated with [ 212 Pb]DOTATATE for 22 h; cell survival was determined using Presto Blue analysis.
ISSN:1027-4510
1819-7094
DOI:10.1134/S102745102007023X