A critical review of isotopic fractionation and interference correction methods for isotope ratio measurements by laser ablation multi-collector inductively coupled plasma mass spectrometry

Laser ablation multi-collector inductively coupled plasma mass spectrometry (LA-MC-ICP-MS) has become a powerful technique for the in situ direct determination of isotope ratios in various solid materials. Unlike conventional solution analysis, LA-MC-ICP-MS offers analysis with high spatial resoluti...

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Bibliographic Details
Published in:Spectrochimica acta. Part B: Atomic spectroscopy 2020-09, Vol.171, p.105929, Article 105929
Main Authors: Zhang, Wen, Hu, Zhaochu
Format: Article
Language:English
Subjects:
Ablation
Contamination
Emission spectroscopy
Fractionation
Inductively coupled plasma mass spectrometry
Interference
Isobaric interference
Isotope analysis
Isotope fractionation
Isotope ratios
Isotopes
Isotopic fractionation/mass bias correction
LA-MC-ICP-MS
Laser ablation
Lasers
Mass spectrometry
Mass spectroscopy
Matrix effect
Methods
Ratios
Sample preparation
Scientific imaging
Spatial analysis
Spatial discrimination
Spatial resolution
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Summary:Laser ablation multi-collector inductively coupled plasma mass spectrometry (LA-MC-ICP-MS) has become a powerful technique for the in situ direct determination of isotope ratios in various solid materials. Unlike conventional solution analysis, LA-MC-ICP-MS offers analysis with high spatial resolution, high sample throughput, minimal sample preparation, and low contamination. Although the performance of LA-MC-ICP-MS has been improved greatly in the past decades, it has its inherent disadvantages such as complex isotopic fractionation/mass bias behavior, severe matrix effect, and isobaric interference, which limits its usage. This review focuses on the latest developments related to isotopic fractionation, matrix effect, and isobaric interference as well as their correction methods for LA-MC-ICP-MS. It is evident that the appropriate correction methods for LA-MC-ICP-MS are essential to obtain accurate and precise isotope ratios and ensure the success of further applications. [Display omitted] •An overview of the cause and solution of mass fractionation and matrix effects in LA-MC-ICP-MS is provided.•Technical and mathematical methods are discussed to eliminate the isobaric interference in LA-MC-ICP-MS.•Technical advances and future development trend of LA-MC-ICP-MS are presented.
ISSN:0584-8547
1873-3565
DOI:10.1016/j.sab.2020.105929