Polyphosphoric acid-promoted synthesis of coumarins lacking substituents at positions 3 and 4

Coumarins have recently emerged as a hot topic of research due to their diverse pharmacological properties. This work described a method for the synthesis of 3,4-diunsubstituted coumarins promoted by polyphosphoric acid (PPA) from salicylaldehydes and acetic anhydride. Various coumarins were produce...

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Bibliographic Details
Published in:Synthetic communications 2020-10, Vol.50 (20), p.3080-3085
Main Authors: Yang, Li-Shou, Wang, Yu, Wang, En-Hua, Yang, Jan, Pan, Xiong, Liao, Xiu, Yang, Xiao-Sheng
Format: Article
Language:English
Subjects:
Condensation
coumarin
polyphosphoric acid
salicylaldehyde
Synthesis
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Summary:Coumarins have recently emerged as a hot topic of research due to their diverse pharmacological properties. This work described a method for the synthesis of 3,4-diunsubstituted coumarins promoted by polyphosphoric acid (PPA) from salicylaldehydes and acetic anhydride. Various coumarins were produced in good to excellent yields.
ISSN:0039-7911
1532-2432
DOI:10.1080/00397911.2020.1792498