Drug Metabolism in Drug Development: A DIA Tutorial for Regulatory Affairs Specialists

• Published in: Drug information journal 1998-01, Vol.32 (1), p.163-167
• Main Authors: Honig, Peter K., Cantilena, Louis R., Santone, Kenneth S.
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Clinical trial. Drug monitoring; Drug development; Drug interaction; Drug interactions; Drug metabolism; General pharmacology; In vivo methods and tests; Medical sciences; Metabolism; Nomenclature; Personal communication; Pharmaceutical industry; Pharmacogenetics; Pharmacology. Drug treatments; Regulatory agencies
• ISSN: 2168-4790; 0092-8615; 2168-4804; 2164-9200
• DOI: 10.1177/009286159803200123

Many drug metabolism, drug-drug interaction, and pharmacogenetics meetings are held each year and are well attended by scientists from the pharmaceutical industry, academia, and worldwide regulatory agencies. Personal communication indicated that large amounts of drug metabolism information passed across the desks of the regulatory affairs specialists either as reports being submitted to or as information requests from regulatory agencies and that, unlike other preclinical or clinical data, there was little appreciation of the meaning or relevance of such information to the overall drug development campaign. The purpose of the tutorial described here was to allow regulatory affairs specialists to gain a working appreciation of the nomenclature, techniques, and usefulness of in vitro and in vivo drug metabolism studies.