Efficient Pd‐Catalyzed C—H Oxidative Bromination of Arenes with Dimethyl Sulfoxide and Hydrobromic Acid

Summary of main observation and conclusion We have developed an efficient Pd‐catalyzed directed C—H bromination protocol, in which dimethyl sulfoxide (DMSO) is employed as oxidant with hydrobromic acid aqueous solution (HBr(aq)) as bromide source. The DMSO/HBr(aq) system, which is novelly and effici...

Full description

Saved in:
Bibliographic Details
Published in:Chinese journal of chemistry 2020-11, Vol.38 (11), p.1245-1251
Main Authors: Yuan, Yizhi, Liang, Yujie, Shi, Shihui, Liang, Yu‐Feng, Jiao, Ning
Format: Article
Language:English
Subjects:
Aqueous solutions
Aromatic compounds
Atom economy
Bromination
Dimethyl sulfoxide
Hydrobromic acid
Oxidants
Oxidation
Oxidizing agents
Palladium
Pd‐catalysis
Sulfoxides
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary of main observation and conclusion We have developed an efficient Pd‐catalyzed directed C—H bromination protocol, in which dimethyl sulfoxide (DMSO) is employed as oxidant with hydrobromic acid aqueous solution (HBr(aq)) as bromide source. The DMSO/HBr(aq) system, which is novelly and efficiently utilized in transition‐metal catalyzed C—H activation, illustrates its practicability by the operational simplicity, inexpensive and readily available starting materials, and high bromide‐atom economy. We have developed an efficient Pd‐catalyzed directed C—H bromination protocol, in which dimethyl sulfoxide (DMSO) is employed as oxidant with hydrobromic acid aqueous solution (HBr(aq)) as bromide source. The DMSO/HBr(aq) system, which is novelly and efficiently utilized in transition‐ metal catalyzed C—H activation, illustrates its practicability by the operational simplicity, inexpensive and readily available starting materials, and high bromide‐atom economy.
ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.202000055