Epstein–Barr virus-associated gastric cancer: disease that requires special approach

Epstein–Barr virus-associated gastric cancer [EBV-associated GC, EBV( +) GC] is a distinct molecular subtype of gastrointestinal (GI) cancers. It accounts for up to 10% of all molecular subtypes of gastric cancer (GC). It has unique genetic and epigenetic features, which determine its definitive phe...

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Bibliographic Details
Published in:Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2020-11, Vol.23 (6), p.951-960
Main Authors: Ignatova, Ekaterina, Seriak, Daria, Fedyanin, Mikhail, Tryakin, Alexey, Pokataev, Ilya, Menshikova, Sofia, Vakhabova, Yuliya, Smirnova, Ksenia, Tjulandin, Sergey, Ajani, Jaffer A.
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adenocarcinoma
Adenocarcinoma - genetics
Adenocarcinoma - virology
B7-H1 Antigen - genetics
Cancer Research
Class I Phosphatidylinositol 3-Kinases - genetics
DNA, Viral
DNA-Binding Proteins - genetics
Drug therapy
Epigenetics
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - genetics
Epstein-Barr Virus Infections - virology
Female
Gastric cancer
Gastroenterology
Herpesvirus 4, Human - genetics
Humans
Janus Kinase 2 - genetics
Localization
Male
Medicine
Medicine & Public Health
Mutation
Oncology
PD-L1 protein
Phenotypes
Prognosis
Programmed Cell Death 1 Ligand 2 Protein - genetics
Proto-Oncogene Proteins - genetics
Repressor Proteins - genetics
Review Article
Stomach Neoplasms - genetics
Stomach Neoplasms - virology
Surgical Oncology
Transcription Factors - genetics
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Summary:Epstein–Barr virus-associated gastric cancer [EBV-associated GC, EBV( +) GC] is a distinct molecular subtype of gastrointestinal (GI) cancers. It accounts for up to 10% of all molecular subtypes of gastric cancer (GC). It has unique genetic and epigenetic features, which determine its definitive phenotype with male and younger age predominance, proximal stomach localization, and diffuse adenocarcinoma histology. EBV( +) GC also has a unique epigenetic profile and mutational status with frequent mutations of PIK3CA , ARID1A and BCOR, and PD-L1 and PD-L2 amplifications, as well. The aim of this review is to highlight clinical significance of EBV( +) GC and prognostic role of EBV infection, and to determine potentially appropriate drug therapy for this disease.
ISSN:1436-3291
1436-3305
DOI:10.1007/s10120-020-01095-z