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Epstein–Barr virus-associated gastric cancer: disease that requires special approach
Epstein–Barr virus-associated gastric cancer [EBV-associated GC, EBV( +) GC] is a distinct molecular subtype of gastrointestinal (GI) cancers. It accounts for up to 10% of all molecular subtypes of gastric cancer (GC). It has unique genetic and epigenetic features, which determine its definitive phe...
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| Published in: | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2020-11, Vol.23 (6), p.951-960 |
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| cites | cdi_FETCH-LOGICAL-c443t-3be7ad5db89cc8a7e6fbcdc8919c9be8b9905ea8adeac62b9aad4688e1c398ac3 |
| container_end_page | 960 |
| container_issue | 6 |
| container_start_page | 951 |
| container_title | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association |
| container_volume | 23 |
| creator | Ignatova, Ekaterina Seriak, Daria Fedyanin, Mikhail Tryakin, Alexey Pokataev, Ilya Menshikova, Sofia Vakhabova, Yuliya Smirnova, Ksenia Tjulandin, Sergey Ajani, Jaffer A. |
| description | Epstein–Barr virus-associated gastric cancer [EBV-associated GC, EBV( +) GC] is a distinct molecular subtype of gastrointestinal (GI) cancers. It accounts for up to 10% of all molecular subtypes of gastric cancer (GC). It has unique genetic and epigenetic features, which determine its definitive phenotype with male and younger age predominance, proximal stomach localization, and diffuse adenocarcinoma histology. EBV( +) GC also has a unique epigenetic profile and mutational status with frequent mutations of
PIK3CA
,
ARID1A
and
BCOR,
and
PD-L1
and
PD-L2
amplifications, as well. The aim of this review is to highlight clinical significance of EBV( +) GC and prognostic role of EBV infection, and to determine potentially appropriate drug therapy for this disease. |
| doi_str_mv | 10.1007/s10120-020-01095-z |
| format | article |
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PIK3CA
,
ARID1A
and
BCOR,
and
PD-L1
and
PD-L2
amplifications, as well. The aim of this review is to highlight clinical significance of EBV( +) GC and prognostic role of EBV infection, and to determine potentially appropriate drug therapy for this disease.</description><identifier>ISSN: 1436-3291</identifier><identifier>EISSN: 1436-3305</identifier><identifier>DOI: 10.1007/s10120-020-01095-z</identifier><identifier>PMID: 32514646</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Abdominal Surgery ; Adenocarcinoma ; Adenocarcinoma - genetics ; Adenocarcinoma - virology ; B7-H1 Antigen - genetics ; Cancer Research ; Class I Phosphatidylinositol 3-Kinases - genetics ; DNA, Viral ; DNA-Binding Proteins - genetics ; Drug therapy ; Epigenetics ; Epstein-Barr virus ; Epstein-Barr Virus Infections - complications ; Epstein-Barr Virus Infections - genetics ; Epstein-Barr Virus Infections - virology ; Female ; Gastric cancer ; Gastroenterology ; Herpesvirus 4, Human - genetics ; Humans ; Janus Kinase 2 - genetics ; Localization ; Male ; Medicine ; Medicine & Public Health ; Mutation ; Oncology ; PD-L1 protein ; Phenotypes ; Prognosis ; Programmed Cell Death 1 Ligand 2 Protein - genetics ; Proto-Oncogene Proteins - genetics ; Repressor Proteins - genetics ; Review Article ; Stomach Neoplasms - genetics ; Stomach Neoplasms - virology ; Surgical Oncology ; Transcription Factors - genetics</subject><ispartof>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2020-11, Vol.23 (6), p.951-960</ispartof><rights>The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2020</rights><rights>The International Gastric Cancer Association and The Japanese Gastric Cancer Association 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c443t-3be7ad5db89cc8a7e6fbcdc8919c9be8b9905ea8adeac62b9aad4688e1c398ac3</citedby><cites>FETCH-LOGICAL-c443t-3be7ad5db89cc8a7e6fbcdc8919c9be8b9905ea8adeac62b9aad4688e1c398ac3</cites><orcidid>0000-0002-8114-7885</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32514646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ignatova, Ekaterina</creatorcontrib><creatorcontrib>Seriak, Daria</creatorcontrib><creatorcontrib>Fedyanin, Mikhail</creatorcontrib><creatorcontrib>Tryakin, Alexey</creatorcontrib><creatorcontrib>Pokataev, Ilya</creatorcontrib><creatorcontrib>Menshikova, Sofia</creatorcontrib><creatorcontrib>Vakhabova, Yuliya</creatorcontrib><creatorcontrib>Smirnova, Ksenia</creatorcontrib><creatorcontrib>Tjulandin, Sergey</creatorcontrib><creatorcontrib>Ajani, Jaffer A.</creatorcontrib><title>Epstein–Barr virus-associated gastric cancer: disease that requires special approach</title><title>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association</title><addtitle>Gastric Cancer</addtitle><addtitle>Gastric Cancer</addtitle><description>Epstein–Barr virus-associated gastric cancer [EBV-associated GC, EBV( +) GC] is a distinct molecular subtype of gastrointestinal (GI) cancers. It accounts for up to 10% of all molecular subtypes of gastric cancer (GC). It has unique genetic and epigenetic features, which determine its definitive phenotype with male and younger age predominance, proximal stomach localization, and diffuse adenocarcinoma histology. EBV( +) GC also has a unique epigenetic profile and mutational status with frequent mutations of
PIK3CA
,
ARID1A
and
BCOR,
and
PD-L1
and
PD-L2
amplifications, as well. The aim of this review is to highlight clinical significance of EBV( +) GC and prognostic role of EBV infection, and to determine potentially appropriate drug therapy for this disease.</description><subject>Abdominal Surgery</subject><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - virology</subject><subject>B7-H1 Antigen - genetics</subject><subject>Cancer Research</subject><subject>Class I Phosphatidylinositol 3-Kinases - genetics</subject><subject>DNA, Viral</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Drug therapy</subject><subject>Epigenetics</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - complications</subject><subject>Epstein-Barr Virus Infections - genetics</subject><subject>Epstein-Barr Virus Infections - virology</subject><subject>Female</subject><subject>Gastric cancer</subject><subject>Gastroenterology</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Humans</subject><subject>Janus Kinase 2 - genetics</subject><subject>Localization</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mutation</subject><subject>Oncology</subject><subject>PD-L1 protein</subject><subject>Phenotypes</subject><subject>Prognosis</subject><subject>Programmed Cell Death 1 Ligand 2 Protein - genetics</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Repressor Proteins - genetics</subject><subject>Review Article</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - virology</subject><subject>Surgical Oncology</subject><subject>Transcription Factors - genetics</subject><issn>1436-3291</issn><issn>1436-3305</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kM9Kw0AQxhdRbK2-gAcJeI7uZrNp1puW-gcKXtTrMtmdtiltmu4kgj35Dr6hT2JCWr15GGZgft_3wcfYueBXgvPhNQkuIh7ydgTXKtwesL6IZRJKydXh_o606LETogXnQmmRHLOejJSIkzjps7dxSRXmxffn1x14H7znvqYQiNY2hwpdMAOqfG4DC4VFfxO4nBAIg2oOVeBxU-ceKaASG34ZQFn6Ndj5KTuawpLwbLcH7PV-_DJ6DCfPD0-j20lo41hWocxwCE65LNXWpjDEZJpZZ1MttNUZppnWXCGk4BBsEmUawMVJmqKwUqdg5YBddr5N7KZGqsxiXfuiiTRRrISKk0iKhoo6yvo1kcepKX2-Av9hBDdtlaar0vB22irNthFd7KzrbIXuV7LvrgFkB1DzKmbo_7L_sf0BqhCCkw</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Ignatova, Ekaterina</creator><creator>Seriak, Daria</creator><creator>Fedyanin, Mikhail</creator><creator>Tryakin, Alexey</creator><creator>Pokataev, Ilya</creator><creator>Menshikova, Sofia</creator><creator>Vakhabova, Yuliya</creator><creator>Smirnova, Ksenia</creator><creator>Tjulandin, Sergey</creator><creator>Ajani, Jaffer A.</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><orcidid>https://orcid.org/0000-0002-8114-7885</orcidid></search><sort><creationdate>20201101</creationdate><title>Epstein–Barr virus-associated gastric cancer: disease that requires special approach</title><author>Ignatova, Ekaterina ; Seriak, Daria ; Fedyanin, Mikhail ; Tryakin, Alexey ; Pokataev, Ilya ; Menshikova, Sofia ; Vakhabova, Yuliya ; Smirnova, Ksenia ; Tjulandin, Sergey ; Ajani, Jaffer A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c443t-3be7ad5db89cc8a7e6fbcdc8919c9be8b9905ea8adeac62b9aad4688e1c398ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdominal Surgery</topic><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - virology</topic><topic>B7-H1 Antigen - genetics</topic><topic>Cancer Research</topic><topic>Class I Phosphatidylinositol 3-Kinases - genetics</topic><topic>DNA, Viral</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Drug therapy</topic><topic>Epigenetics</topic><topic>Epstein-Barr virus</topic><topic>Epstein-Barr Virus Infections - complications</topic><topic>Epstein-Barr Virus Infections - genetics</topic><topic>Epstein-Barr Virus Infections - virology</topic><topic>Female</topic><topic>Gastric cancer</topic><topic>Gastroenterology</topic><topic>Herpesvirus 4, Human - genetics</topic><topic>Humans</topic><topic>Janus Kinase 2 - genetics</topic><topic>Localization</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mutation</topic><topic>Oncology</topic><topic>PD-L1 protein</topic><topic>Phenotypes</topic><topic>Prognosis</topic><topic>Programmed Cell Death 1 Ligand 2 Protein - genetics</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Repressor Proteins - genetics</topic><topic>Review Article</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - virology</topic><topic>Surgical Oncology</topic><topic>Transcription Factors - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ignatova, Ekaterina</creatorcontrib><creatorcontrib>Seriak, Daria</creatorcontrib><creatorcontrib>Fedyanin, Mikhail</creatorcontrib><creatorcontrib>Tryakin, Alexey</creatorcontrib><creatorcontrib>Pokataev, Ilya</creatorcontrib><creatorcontrib>Menshikova, Sofia</creatorcontrib><creatorcontrib>Vakhabova, Yuliya</creatorcontrib><creatorcontrib>Smirnova, Ksenia</creatorcontrib><creatorcontrib>Tjulandin, Sergey</creatorcontrib><creatorcontrib>Ajani, Jaffer A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ignatova, Ekaterina</au><au>Seriak, Daria</au><au>Fedyanin, Mikhail</au><au>Tryakin, Alexey</au><au>Pokataev, Ilya</au><au>Menshikova, Sofia</au><au>Vakhabova, Yuliya</au><au>Smirnova, Ksenia</au><au>Tjulandin, Sergey</au><au>Ajani, Jaffer A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epstein–Barr virus-associated gastric cancer: disease that requires special approach</atitle><jtitle>Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association</jtitle><stitle>Gastric Cancer</stitle><addtitle>Gastric Cancer</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>23</volume><issue>6</issue><spage>951</spage><epage>960</epage><pages>951-960</pages><issn>1436-3291</issn><eissn>1436-3305</eissn><abstract>Epstein–Barr virus-associated gastric cancer [EBV-associated GC, EBV( +) GC] is a distinct molecular subtype of gastrointestinal (GI) cancers. It accounts for up to 10% of all molecular subtypes of gastric cancer (GC). It has unique genetic and epigenetic features, which determine its definitive phenotype with male and younger age predominance, proximal stomach localization, and diffuse adenocarcinoma histology. EBV( +) GC also has a unique epigenetic profile and mutational status with frequent mutations of
PIK3CA
,
ARID1A
and
BCOR,
and
PD-L1
and
PD-L2
amplifications, as well. The aim of this review is to highlight clinical significance of EBV( +) GC and prognostic role of EBV infection, and to determine potentially appropriate drug therapy for this disease.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>32514646</pmid><doi>10.1007/s10120-020-01095-z</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8114-7885</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2020-11, Vol.23 (6), p.951-960 |
| issn | 1436-3291 1436-3305 |
| language | eng |
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| subjects | Abdominal Surgery Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - virology B7-H1 Antigen - genetics Cancer Research Class I Phosphatidylinositol 3-Kinases - genetics DNA, Viral DNA-Binding Proteins - genetics Drug therapy Epigenetics Epstein-Barr virus Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - genetics Epstein-Barr Virus Infections - virology Female Gastric cancer Gastroenterology Herpesvirus 4, Human - genetics Humans Janus Kinase 2 - genetics Localization Male Medicine Medicine & Public Health Mutation Oncology PD-L1 protein Phenotypes Prognosis Programmed Cell Death 1 Ligand 2 Protein - genetics Proto-Oncogene Proteins - genetics Repressor Proteins - genetics Review Article Stomach Neoplasms - genetics Stomach Neoplasms - virology Surgical Oncology Transcription Factors - genetics |
| title | Epstein–Barr virus-associated gastric cancer: disease that requires special approach |
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