Quantification of fat-soluble vitamins and their metabolites in biological matrices: an updated review

Fat-soluble vitamins (FSVs) are micronutrients essential in maintaining normal physiological function, metabolism and human growth. Ongoing increased awareness regarding FSV concentrations and their impact on human growth along with disease progression warrant the need of developing selective and se...

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Bibliographic Details
Published in:Bioanalysis 2020-05, Vol.12 (9), p.625-640
Main Authors: Zhang, Yuning, Bala, Veenu, Mao, Zhihao, Chhonker, Yashpal S, Murry, Daryl J
Format: Article
Language:English
Subjects:
Acids
biological samples
Biomarkers
Calibration
Cardiovascular disease
Chromatography
fat-soluble vitamins
high performance LC
Ions
LC–MS/MS
Metabolites
Methods
Micronutrients
Physiology
Quantitation
Vegetables
Vitamin A
Vitamin D
Vitamin deficiency
Vitamin E
Vitamins
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Summary:Fat-soluble vitamins (FSVs) are micronutrients essential in maintaining normal physiological function, metabolism and human growth. Ongoing increased awareness regarding FSV concentrations and their impact on human growth along with disease progression warrant the need of developing selective and sensitive analytical methods. LC–MS/MS is currently the method of choice for accurate quantitation of FSVs. However, there are multiple approaches for extraction, separation and calibration of FSVs in biological matrices. This review discusses recent LC–MS/MS methods for the simultaneous quantification of FSVs in biological matrices and summarizes sample pretreatment procedures, chromatographic conditions and calibration approaches. Current challenges and clinical applications in various disease states are also highlighted.
ISSN:1757-6180
1757-6199
DOI:10.4155/bio-2020-0069