Psychoactive substances in human breast milk: a review of analytical strategies for their investigation

WHO recommends breastfeeding for the first 6 months of newborn's life. Due to its physicochemical properties, breast milk may contain undesirable components originated from mother's feeding, medication and illicit drugs consumption. Some of these substances transferred from bloodstream to...

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Bibliographic Details
Published in:Bioanalysis 2020-09, Vol.12 (17), p.1263-1274
Main Authors: Ramos Santos Jr, Wilson José, De Martinis, Bruno Spinosa
Format: Article
Language:English
Subjects:
Amphetamines
Analgesics
analytical chemistry
Babies
Breast feeding
Breast milk
Breastfeeding & lactation
Caffeine
Chromatography
Cocaine
Consumption
Drug dosages
Drug use
drugs of abuse
forensic toxicology
human breast milk
Infections
Investigations
Lipids
Medical personnel
Mothers
Physicochemical properties
Plasma
Postpartum period
Pregnancy
psychoactive substances
Psychotropic drugs
review
sample preparation
Tetrahydrocannabinol
THC
Urine
Womens health
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Summary:WHO recommends breastfeeding for the first 6 months of newborn's life. Due to its physicochemical properties, breast milk may contain undesirable components originated from mother's feeding, medication and illicit drugs consumption. Some of these substances transferred from bloodstream to milk and delivered to the infant can cause harmful effects. For the last decades, analytical advances enabled the analysis of several substances in milk using different techniques. Thereby, it is possible to evaluate infant's level of exposure to these substances. This review presents the information published in the main scientific dissemination media about psychoactive drugs investigation in human breast milk, involving the sample preparation techniques and chromatographic validated methods developed in the past 10 years.
ISSN:1757-6180
1757-6199
DOI:10.4155/bio-2020-0155