Spinal‐Cord Injury Treatment: Effective Modulation of CNS Inhibitory Microenvironment using Bioinspired Hybrid‐Nanoscaffold‐Based Therapeutic Interventions (Adv. Mater. 43/2020)

Current treatment of central nervous system (CNS) injuries has been hampered by the neuroinhibitory microenvironment. In article number 2002578, Jae K. Lee, Ki‐Bum Lee, and co‐workers develop a method to effectively treat CNS injuries by delivering anti‐inflammatory drugs in vivo and providing a per...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2020-10, Vol.32 (43), p.n/a
Main Authors: Yang, Letao, Conley, Brian M., Cerqueira, Susana R., Pongkulapa, Thanapat, Wang, Shenqiang, Lee, Jae K., Lee, Ki‐Bum
Format: Article
Language:English
Subjects:
Biodegradability
biomaterials
Central nervous system
Drug delivery systems
Fibrosis
In vivo methods and tests
Injuries
Injury prevention
inorganic–organic hybrid nanomaterials
Materials science
nanoscaffolds
neural tissue engineering
Scars
spinal cord injury
Surgical implants
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Summary:Current treatment of central nervous system (CNS) injuries has been hampered by the neuroinhibitory microenvironment. In article number 2002578, Jae K. Lee, Ki‐Bum Lee, and co‐workers develop a method to effectively treat CNS injuries by delivering anti‐inflammatory drugs in vivo and providing a permissive neural matrix using biodegradable nanoscaffolds. Implantation of drug‐loaded nanoscaffolds to spinal‐cord injury sites reduces macrophage infiltration, suppresses fibrotic scarring, and thereby promotes functional recovery.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.202070325