Fabrication of an electrochemical mesalazine sensor based on ZIF-67

• Published in: Measurement : journal of the International Measurement Confederation 2020-12, Vol.165, p.108140, Article 108140
• Main Authors: Sohouli, Esmail, Sadeghpour Karimi, Meisam, Marzi Khosrowshahi, Elnaz, Rahimi-Nasrabadi, Mehdi, Ahmadi, Farhad
• Format: Article
• Language: English
• Subjects: Electrochemical analysis; Electrochemical impedance spectroscopy; Electrochemical sensor; Electrodes; Mesalazine; Modified carbon paste electrode; Nanoparticles; Oxidation; Silver chloride; Standard deviation; Urine; Voltammetry; ZIF-67
• ISSN: 0263-2241; 1873-412X
• DOI: 10.1016/j.measurement.2020.108140

[Display omitted] •Modified electrodeinvolves ZIF-67 nanoparticles were used.•A highly sensitive method was developed for Mesalazine detection.•Wide linear dynamic range (0.03–50 μM) and low detection limit of 0.01 µM were obtained.•The suggested method was successfully applied for Mesalazine detection in real sample. This paper describes the application of ZIF-67 nanoparticles for carbon paste electrode (CPE) modification for sensitive voltammetric detection of mesalazine (MSA). The characterization of as-synthesized ZIF-67 nanoparticles was investigated by different techniques. Furthermore, the electrochemical behavior of the modified CPE (MCPE) was investigated using EIS (electrochemical impedance spectroscopy) and CV (cyclic voltammetry) methods. The results showed an irreversible oxidation peak for MSA around 0.540 V vs. the Ag/AgCl reference electrode. Thecurve of the peak current of differential pulse voltammetry (DPV) vs MSA concentration was linear in the range of 0.03–50 μM with a detection limit of 0.01 µM. The prepared sensor presents good repeatability with acceptable relative standard deviation (RSD) values. Finally, the prepared electrode was successfully used in human serum and urine as real samples.