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Antibacterial phloroglucinols derivatives from the leaves of Mallotus oppositifolius (Geisler) Müll. Arg. (Euphorbiaceae)

From the ethno-medicinally used leaves of Mallotus oppositifolius, four acylphloroglucinol derivatives, namely Acronyculatin SU (1–3) and Mallotojaponin D (4) were isolated along with seven known compounds (5–11). Structures were elucidated by comprehensive spectroscopic analyses and HRMS data. Abso...

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Bibliographic Details
Published in:Fitoterapia 2020-04, Vol.142, p.104527-6, Article 104527
Main Authors: Tchangoue, Yvan Anderson Ngandjui, Tchamgoue, Joseph, Lunga, Paul Keilah, Knepper, Janosch, Paltinean, Ramona, Ibrom, Kerstin, Crișan, Gianina, Kouam, Simeon Fogue, Ali, Muhammad Shaiq, Schulz, Stefan
Format: Article
Language:English
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Summary:From the ethno-medicinally used leaves of Mallotus oppositifolius, four acylphloroglucinol derivatives, namely Acronyculatin SU (1–3) and Mallotojaponin D (4) were isolated along with seven known compounds (5–11). Structures were elucidated by comprehensive spectroscopic analyses and HRMS data. Absolute configurations were assigned by careful comparison of their specific optical rotation with those of closely related compounds. Compounds 1, 2, 6 and 11 demonstrated inhibitory activity against the bacterial strains E. coli, S. aureus, S. typhi, P. aeruginosa with minimum inhibitory concentration (MIC) values ranging from 3.125 to 50 μg/ml. [Display omitted] •Four acylphloroglucinol derivatives were isolated from Mallotus oppositifolius.•Structures were elucidated by comprehensive spectroscopic analyses and HRMS data.•Some of the compounds displayed significant antibacterial activity.
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2020.104527