Synthesis and cytotoxic activity of various alkyl 2-{di[(diethoxy phosphoryl)methyl]amino}ester derivatives

We have been synthesized simple, efficient various alkyl 2-{di[(diethoxy phosphoryl) methyl]amino}ester derivatives by reacting amino acid esters 1(a-j), paraformaldehyde and two molar equivalents of diethyl hydrogenphosphonate (2) in tetrahydrofuran at 55-65 °C for 10 hrs. All the compounds 3(a-j)...

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Bibliographic Details
Main Authors: Reddy, C. Bhupendra, Reddy, N. Bakthavatchala, Raju, C. Naga
Format: Conference Proceeding
Language:English
Subjects:
Colon
Derivatives
Esters
Leukemia
Tetrahydrofuran
Toxicity
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Summary:We have been synthesized simple, efficient various alkyl 2-{di[(diethoxy phosphoryl) methyl]amino}ester derivatives by reacting amino acid esters 1(a-j), paraformaldehyde and two molar equivalents of diethyl hydrogenphosphonate (2) in tetrahydrofuran at 55-65 °C for 10 hrs. All the compounds 3(a-j) were assessed for cytotoxicity against some important types of human chronic myeloid leukemia cells (K-562) and human colon carcinoma cells (Colo-205) along with noncancerous human embryonic kidney cells (HEK-293).
ISSN:0094-243X
1551-7616
DOI:10.1063/5.0018370