Polycaprolactone‐based hotmelt adhesive for hernia‐mesh fixation

Mesh fixation during hernia repair surgery is an important factor contributing to post‐operative chronic pain. Nerve damage and parenchymal penetration caused by staples and tacks can be significantly reduced using tissue adhesives. However, the application of adhesives on a wet substrate is challen...

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Bibliographic Details
Published in:Polymers for advanced technologies 2020-12, Vol.31 (12), p.3194-3201
Main Authors: Roisman, Sabrina, Dotan, Ana L., Lewitus, Dan Y.
Format: Article
Language:English
Subjects:
Adhesion tests
adhesive
Adhesive strength
Adhesives
Burst tests
Catechol
Damage
Design of experiments
Factorial design
Fixation
Hernias
hernia‐mesh
hotmelt
hydrocaffeic acid
Melt temperature
Polycaprolactone
Polymers
Staples
Substrates
Wettability
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Summary:Mesh fixation during hernia repair surgery is an important factor contributing to post‐operative chronic pain. Nerve damage and parenchymal penetration caused by staples and tacks can be significantly reduced using tissue adhesives. However, the application of adhesives on a wet substrate is challenging because the presence of water leads to poor adhesion, and the control over mesh fixation and positioning during application is limited. Herein, a polymer‐based hotmelt adhesive was developed to allow mesh fixation via “on‐demand,” rapid, and precise application, along with adequate adhesive strength. The introduction of catechol 3,4‐dihydroxyhydrocinnamic acid into a polycaprolactone matrix (20% w/w) resulted in a significant reduction in the melting temperature of the polymer (from 57°C to 49°C), and high adhesive strength when used for attaching a commercial polyester‐based hernia‐mesh on fresh poultry tissue (7.1 ± 1.9 kPa). To further reduce the application temperature and improve the tissue wettability of the adhesive, amorphous poly(trimethylene carbonate‐co‐polycaprolactone) and low‐molecular‐weight polycaprolactone were blended with the adhesive via a three‐level full‐factorial design of experiment. The strength of the resulting adhesive with the optimal composition was comparable to that of a commercial cyanoacrylate adhesive, both in terms of lap shear and ball‐burst tests on fresh porcine tissue. The hotmelt adhesive represents a new approach toward hernia‐mesh fixation, potentially avoiding collateral tissue damage.
ISSN:1042-7147
1099-1581
DOI:10.1002/pat.5044