Fatty Acids and Sterol Rich Stem Back Extract of Shorea Roxburghii Attenuates Hyperglycemia, Hyperlipidemia, and Oxidative Stress in Diabetic Rats

• Published in: European journal of lipid science and technology 2020-11, Vol.122 (11), p.n/a
• Main Authors: Makinde, Emmanuel Ayobami, Radenahmad, Nisaudah, Zaman, Raihan Uz, Olatunji, Opeyemi Joshua
• Format: Article
• Language: English
• Subjects: Alanine; Alanine transaminase; Alkaline phosphatase; Antioxidants; Aspartate aminotransferase; Blood; Blood glucose; Catalase; Cholesterol; Creatinine; Diabetes; Diabetes mellitus; Diet; Dietary supplements; Fatty acids; Functional foods & nutraceuticals; Glutathione; Glutathione peroxidase; Hemoglobin; High fat diet; high‐fat diets; Hyperglycemia; Hyperlipidemia; Insulin; insulin resistance; Insulin secretion; Kidneys; Lipids; Liver; Low density lipoprotein; Malondialdehyde; Oxidation; Oxidative stress; Pancreas; Peroxidase; Rodents; Shorea roxburghii; Stems; Sterols; Superoxide dismutase; Triglycerides; Urea
• ISSN: 1438-7697; 1438-9312
• DOI: 10.1002/ejlt.202000151

This study investigates the effect of fatty acid and sterol rich extract from the stem back of S. roxburghii (MESS) on hyperglycemia, hyperlipidemia, and oxidative stress induced by high fat diet/streptozotocin (HFD/STZ) in rats. The results indicate that MESS (100 and 400 mg kg−1) reduces fasting blood glucose (FBG), serum lipids including total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL‐C), aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT), creatinine, blood urea nitrogen (BUN), and glycated hemoglobin (HbA1c). In addition, MESS significantly elevates antioxidant enzymes activities including superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH‐Px) and suppressed malondialdehyde (MDA) and myeloperoxidase (MPO) content in the kidney and liver tissues. Furthermore, MESS enhances insulin secretion and ameliorate histological alterations in the pancreas, kidney, and liver treated diabetic rats. These results demonstrate that MESS exerts potent anti‐hyperglycemic, antihyperlipidemic, and antioxidant effects and may have potentials to prevent diabetes. Practical Applications: The effects of the stem back of S. roxburghii (MESS) on hyperglycemia, hyperlipidemia, and oxidative stress induced by high fat diet/streptozotocin (HFD/STZ) in rats are investigated. The results show that supplementation with MESS counteracted hyperglycemia, hyperlipidemia, and oxidative stress in diabetic rats indicating its ameliorative effect on diabetes and hyperglycemia induced oxidative stress. This research provides a theoretical basis for the development of functional nutraceuticals from MESS diabetic patients. This study investigates the effect of fatty acid and sterol rich extract from the stem back of S. roxburghii (MESS) on hyperglycemia, hyperlipidemia, and oxidative stress induced by high fat diet/streptozotocin (HFD/STZ) in rats.