Effects of inflammatory stimulation during pregnancy on mesenteric vascular function of offspring rats

To evaluate the effects of inflammatory stimulation during pregnancy on the mesenteric vascular function of offspring rats. Twenty-four Sprague-Dawley pregnant rats were randomly divided into a control group and a lipopolysaccharide (LPS) stimulation group that were intraperitoneally injected with n...

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Bibliographic Details
Published in:Revista argentina de clínica psicológica 2020-01, Vol.29 (3), p.178
Main Authors: Zheng, Juntao, Xiao, Huili, Song, Linxiao, Sun, Aichun
Format: Article
Language:eng ; spa
Subjects:
Blood pressure
Blood vessels
Control groups
Pregnancy
Rats
Stimulation
Veins & arteries
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Summary:To evaluate the effects of inflammatory stimulation during pregnancy on the mesenteric vascular function of offspring rats. Twenty-four Sprague-Dawley pregnant rats were randomly divided into a control group and a lipopolysaccharide (LPS) stimulation group that were intraperitoneally injected with normal saline and LPS (0.79 mg/kg) on the 8th, 10th and 12th days of pregnancy respectively. At 8 weeks of age, 12 male pups were randomly selected from each group for subsequent experiments. Their blood pressures at 9, 11, 13 and 15 weeks of age were measured noninvasively at the tail. The responses of mesenteric tertiary blood vessels to 10-10~10-5 mol/L angiotensin II (AngII) were observed. AT1R expression in mesenteric vessels was detected by Western blotting. The systolic blood pressure of the LPS stimulation group was significantly higher than that of the control group at 9, 11, 13 and 15 W (P
ISSN:0327-6716
1851-7951
DOI:10.24205/03276716.2020.711