Loading…
Non-enzymatic sensor based on nitrogen-doped graphene modified with Pd nano-particles and NiAl layered double hydroxide for glucose determination in blood
Herein, a novel highly sensitive and selective non-enzymatic glucose sensor was developed. This sensor was prepared with a one-step electrodeposition process, which means that the palladium nanoparticles and NiAl layered double hydroxide were electrosynthesized simultaneously (Pd-NiAl-LDH) on a grap...
Saved in:
Published in: | Journal of electroanalytical chemistry (Lausanne, Switzerland) Switzerland), 2020-08, Vol.871, p.114285, Article 114285 |
---|---|
Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Herein, a novel highly sensitive and selective non-enzymatic glucose sensor was developed. This sensor was prepared with a one-step electrodeposition process, which means that the palladium nanoparticles and NiAl layered double hydroxide were electrosynthesized simultaneously (Pd-NiAl-LDH) on a graphite sheet electrode (GS) covered by nitrogen-doped functionalized graphene (NFG). The sensing performance was investigated by linear sweep voltammetry (LSV), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS) and chronoamperometry (CA) techniques. The results revealed that the one-step electrodeposition of Pd-NiAl-LDH nanocomposite on NFG provided a large surface area containing Ni and Pd electroactive centers and enhanced the electron transfer. This resulted in a remarkable effect on signal amplification toward glucose oxidation, with a wide linear range from 500 nM to 10 mM, an acceptable sensitivity of 315.46 μA. cm−2. dec−1 and a low detection limit of 234 nM based on a signal to noise ratio of 3. The relative standard deviation (RSD%) in all detection tests was lower than 5% and also the performance of fabricated GS/NFG/Pd-NiAl-LDH electrode which investigated in human real samples including serum, plasma and blood was acceptable, indicating the ability of the fabricated sensor in biological and clinical applications.
•The Pd-NiAl-LDH nano-composite was prepared via one-step electrodeposition process.•The composite had an excellent electroactivity toward glucose oxidation.•NFG prepared a large surface area for electrodeposition of Ni and Pd active centers.•The reproducibility, repeatability and stability of the proposed sensor was good.•Fabricated sensor has an acceptable performance in human serum, plasma and blood. |
---|---|
ISSN: | 1572-6657 1873-2569 |
DOI: | 10.1016/j.jelechem.2020.114285 |