The effect of ethenyltrimethoxysilane modification of nano bioactive glass on the physiochemical and mechanical properties and in vitro bioactivity of poly(lactide- co -glycolide)/poly(trimethylene carbonate) composite

A new method was adopted to improve the dispersion of nanoparticles in a polymer matrix. The nano bioactive glass (NBG) was successfully modified by silane coupling agent ethenyltrimethoxysilane (YDH171). A series of PLGA/PTMC/YDH-NBG composites with different amounts of surface modifier YDH-NBG wer...

Full description

Saved in:
Bibliographic Details
Published in:New journal of chemistry 2020-11, Vol.44 (44), p.19227-19237
Main Authors: Qi, Jin, Zhang, Tianyao, Xiao, Jianping, Zhang, Qianmao, Xiong, Chengdong
Format: Article
Language:English
Subjects:
Biocompatibility
Bioglass
Biological activity
Biomedical materials
Chemical precipitation
Composite materials
Contact angle
Coupling agents
Crystallization
Glass fiber reinforced plastics
Mechanical properties
Morphology
Nanoparticles
Physiochemistry
Surface water
Thermodynamic properties
Tissue engineering
Toxicity
Wettability
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A new method was adopted to improve the dispersion of nanoparticles in a polymer matrix. The nano bioactive glass (NBG) was successfully modified by silane coupling agent ethenyltrimethoxysilane (YDH171). A series of PLGA/PTMC/YDH-NBG composites with different amounts of surface modifier YDH-NBG were prepared by solution co-precipitation. The mechanical properties, fracture morphology, thermal properties, crystallization process, surface water wettability, biomineralization in vitro and bioactivity in vitro of PLGA/PTMC/YDH-NBG composites were investigated. The results showed that a higher amount of YDH-NBG would cause agglomeration in the PLGA/PTMC composite and reduce the mechanical properties of the PLGA/PTMC/YDH-NBG composite, although it could promote the PLGA crystallization. The PLGA/PTMC/YDH-NBG composite containing 5 wt% YDH-NBG had the best mechanical properties and crystallinity among all ternary composites. The POM results showed that PLGA/PTMC/YDH-NBG had the fastest crystallization rate, which indicated that YDH-NBG acted as a nucleating agent and might have a synergetic effect on the accelerated PLGA crystallization. When adding YDH-NBG, the contact angle of the ternary composite increased. Moreover, the PLGA/PTMC/YDH-NBG composite exhibited good biomineralization, better biocompatibility and no toxicity. Therefore, we concluded that PLGA/PTMC/YDH-NBG composites appear to be a promising biomaterial for bone tissue engineering.
ISSN:1144-0546
1369-9261
DOI:10.1039/D0NJ03859H