Sensitive Voltammetric Detection of Chloroquine Drug by Applying a Boron-Doped Diamond Electrode

In this research, a boron-doped diamond (BDD) electrode has been explored to detect the chloroquine drug. The electrochemical performance of BDD electrode towards the irreversible anodic response of chloroquine was investigated by subjecting this electrode to the cathodic (−0.5 A cm−2 by 180 s, gene...

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Bibliographic Details
Published in:C (Basel) 2020-12, Vol.6 (4), p.75
Main Authors: Oliveira, Geiser Gabriel, Azzi, Déborah Christine, Silva, Tiago Almeida, Oliveira, Paulo Roberto de, Fatibello-Filho, Orlando, Janegitz, Bruno Campos
Format: Article
Language:English
Subjects:
Analgesics
Boron
boron-doped diamond
Caffeine
Carbon
chloroquine
Coronaviruses
Correlation coefficients
Diamonds
Drug dosages
electroanalysis
Electrochemical analysis
Electrodes
Morphology
Pharmaceuticals
pharmaceutics
Radio frequency plasma
Silicon wafers
square-wave voltammetry
Voltammetry
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Summary:In this research, a boron-doped diamond (BDD) electrode has been explored to detect the chloroquine drug. The electrochemical performance of BDD electrode towards the irreversible anodic response of chloroquine was investigated by subjecting this electrode to the cathodic (−0.5 A cm−2 by 180 s, generating a predominantly hydrogen-terminated surface) and anodic (+0.5 A cm−2 by 30 s, oxygen-terminated surface) pretreatments. The cathodically pretreated BDD electrode ensured a better-defined anodic peak and higher current intensity. Thus, by applying the cathodically pretreated BDD electrode and square-wave voltammetry (SWV), the analytical curve was linear from 0.01 to 0.25 µmol L−1 (correlation coefficient of 0.994), with sensitivity and limit of detection of 12.2 µA L µmol−1 and 2.0 nmol−1, respectively. This nanomolar limit of detection is the lowest recorded so far with modified and unmodified electrodes.
ISSN:2311-5629
2311-5629
DOI:10.3390/c6040075