Variability in in vitro biofilm production and antimicrobial sensitivity pattern among Pasteurella multocida strains

Biofilm production, hitherto an uncharacterized feature among circulating Pasteurella multocida strains, was studied along with the antibiotic susceptibility pattern. On the basis of biofilm formation ability, all the strains were categorized into four groups under six different culture conditions:...

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Bibliographic Details
Published in:Biofouling (Chur, Switzerland) Switzerland), 2020-09, Vol.36 (8), p.938-950
Main Authors: Prajapati, Awadhesh, Chanda, Mohammed Mudassar, Dhayalan, Arul, Yogisharadhya, Revanaiah, Chaudhary, Jitendra Kumar, Mohanty, Nihar Nalini, Shivachandra, Sathish Bhadravati
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Infective Agents
Antibiotics
Antiinfectives and antibacterials
Antimicrobial resistance
Azithromycin
biofilm
Biofilms
Enrofloxacin
Microbial Sensitivity Tests
Model based analysis
Pasteurella multocida
strain diversity
TadD gene
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Summary:Biofilm production, hitherto an uncharacterized feature among circulating Pasteurella multocida strains, was studied along with the antibiotic susceptibility pattern. On the basis of biofilm formation ability, all the strains were categorized into four groups under six different culture conditions: strong biofilm-forming (22%), moderate (19%), weak (51%), and non-adherent (7%). Strains from serogroups A and B formed significant biofilms in at least one culture condition whereas strains from serogroup D were unable to form biofilms. All strains were found to be susceptible to tetracycline. In addition, the correlation between diverse factors (host, capsule type, clinical condition and the tadD gene) as well as antimicrobial susceptibility in biofilm production were analyzed by Joint distribution models, and showed that enrofloxacin and azithromycin resistant strains were positively correlated with strong biofilm production.
ISSN:0892-7014
1029-2454
DOI:10.1080/08927014.2020.1833192