Recent advances in 1,4-functional group migration-mediated radical fluoroalkylation of alkenes and alkynes

Recently, the combination of radical fluoroalkylation of alkenyl or alkynyl moieties and 1,4-functional group migration (1,4-FGM) has emerged as a powerful strategy for the synthesis of fluorine-containing compounds. In this article, some representative reactions of 1,4-FGM-mediated radical fluoroal...

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Published in:Organic & biomolecular chemistry 2020-11, Vol.18 (44), p.8975-8993
Main Authors: Chen, Ya-Jing, Qu, Ya-Li, Li, Xiang, Wang, Chuan-Chuan
Format: Article
Language:English
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Alkenes
Alkynes
Fluorine
Functional groups
Substrates
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description Recently, the combination of radical fluoroalkylation of alkenyl or alkynyl moieties and 1,4-functional group migration (1,4-FGM) has emerged as a powerful strategy for the synthesis of fluorine-containing compounds. In this article, some representative reactions of 1,4-FGM-mediated radical fluoroalkylation of N -(arylsulfonyl)acrylamides, tertiary alcohol-containing alkynes, tertiary alcohol-containing alkenes and intermolecular 1,4-FGM-type substrates have been discussed based on the types of substrates. In this article, some representative reactions of 1,4-functional group migration-mediated radical fluoroalkylation of alkenes and alkynes have been discussed and reviewed based on the types of substrates.
doi_str_mv 10.1039/d0ob01649g
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subjects Alkenes
Alkynes
Fluorine
Functional groups
Substrates
title Recent advances in 1,4-functional group migration-mediated radical fluoroalkylation of alkenes and alkynes
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