Deoxygenative 1,1‐Bis‐trifluoromethylthiolation of Aromatic Aldehydes to Access Bis(trifluoromethylthio)methylarenes

A deoxygenative 1,1‐bis‐trifluoromethylthiolation of readily available aromatic aldehydes with AgSCF3 in the presence of KI and (NH4)2SO4 was established. This reaction delivered a series of bis(trifluoromethylthio)methylarenes in moderate to high yields. The precise control of the generation and de...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2020-11, Vol.362 (22), p.5031-5035
Main Authors: Liu, Yin‐Li, Xu, Xiu‐Hua, Qing, Feng‐Ling
Format: Article
Language:English
Subjects:
1,1-Bis-trifluoromethylthiolation
Addition
Aldehydes
Ammonium sulfate
Deoxygenation
Substitution
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Summary:A deoxygenative 1,1‐bis‐trifluoromethylthiolation of readily available aromatic aldehydes with AgSCF3 in the presence of KI and (NH4)2SO4 was established. This reaction delivered a series of bis(trifluoromethylthio)methylarenes in moderate to high yields. The precise control of the generation and decomposition of SCF3 anion is the key to the successful transformation.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202000861