Construction of Boronated γ‐Lactams via Palladium‐Catalyzed Intramolecular Boryldifluoroalkylation of Alkenes

An approach for the preparation of boronated γ‐lactams via palladium‐catalyzed boryldifluoroalkylation of alkenes with α‐bromodifluoroacetamides was developed. This method exhibits good functional group tolerance. Various boronated products were obtained in moderate to good yields for 1 h. Mechanist...

Full description

Saved in:
Bibliographic Details
Published in:Advanced synthesis & catalysis 2020-11, Vol.362 (22), p.5009-5013
Main Authors: Lin, Wu‐Jie, Wang, Yu‐Zhao, Zou, Jian‐Yu, Zhao, Yi‐Chuan, Wang, Jin‐Lin, Liu, Xue‐Yuan
Format: Article
Language:English
Subjects:
Alkenes
boronation
difluoroalkylation
difunctionalization
Functional groups
Palladium
palladium-catalyzed
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An approach for the preparation of boronated γ‐lactams via palladium‐catalyzed boryldifluoroalkylation of alkenes with α‐bromodifluoroacetamides was developed. This method exhibits good functional group tolerance. Various boronated products were obtained in moderate to good yields for 1 h. Mechanistic studies indicated that this reaction may involve an intramolecular radical cascade cyclization process.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202000786