Fluorogenic Pt complexes distinguish the quantity and folding behavior of RNA G-quadruplexes between live cancerous and healthy cells

Two Pt complexes with high quantum yields and photostability, and low cytotoxicity, were developed to track RNA G-quadruplexes (GQs) in live cells. Higher number and intensity, and longer lifetime of fluorescent foci in cancer cells than those in healthy cells suggest that the quantity and folding d...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-11, Vol.56 (92), p.14459-14462
Main Authors: He, Lei, Meng, Zhenyu, Guo, Qianqian, Wu, Xiangyang, Teulade-Fichou, Marie-Paule, Yeow, Edwin Kok Lee, Shao, Fangwei
Format: Article
Language:English
Subjects:
Biomarkers
Crystallography
Fluorescence
Folding
Toxicity
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Summary:Two Pt complexes with high quantum yields and photostability, and low cytotoxicity, were developed to track RNA G-quadruplexes (GQs) in live cells. Higher number and intensity, and longer lifetime of fluorescent foci in cancer cells than those in healthy cells suggest that the quantity and folding dynamics of RNA GQs could not only correlate to their biological functions, but be two novel biomarkers to characterize cancerous cells. Fluorogenic Pt complexes were developed to track and compare the intracellular un/folding behaviors of RNA G-quadruplexes among different cell lines.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc05622g