Antifungal activity of oils macerates of North Sardinia plants against Candida species isolated from clinical patients with candidiasis

Antibiotic resistance is one of the bigger problem of public health: the rise of multi-drug resistant organisms causes a challenge in the treatment of infective diseases. Anti-Candida resistance to conventional antifungal agents has increased in the last period. Our research was intended to evaluate...

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Bibliographic Details
Published in:Natural product research 2020-11, Vol.34 (22), p.3280-3284
Main Authors: Donadu, M.G., Usai, D., Marchetti, M., Usai, M., Mazzarello, V., Molicotti, P., Montesu, M.A., Delogu, G., Zanetti, S.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antibiotic resistance
Antibiotics
Antifungal activity
Antifungal agents
Antifungal Agents - pharmacology
Antiinfectives and antibacterials
Antimicrobial activity
Candida
Candida - drug effects
Candida - isolation & purification
Candida krusei
Candida spp
Candidiasis
Candidiasis - drug therapy
Candidiasis - microbiology
Clinical isolates
Drug resistance
Drug Resistance, Fungal
Female
Fungicides
Health services
Helichrysum - chemistry
Humans
Hypericum - chemistry
infections
Italy
Male
Medical treatment
Microbial Sensitivity Tests
Middle Aged
Multidrug resistance
Oils macerates
Patients
Plant Oils - pharmacology
Public health
Young Adult
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Summary:Antibiotic resistance is one of the bigger problem of public health: the rise of multi-drug resistant organisms causes a challenge in the treatment of infective diseases. Anti-Candida resistance to conventional antifungal agents has increased in the last period. Our research was intended to evaluate antimicrobial activity of oil macerate (OM) of Helichrysum microphyllum Cambess. subsp. tyrrhenicum Bacch., Brullo & Giusso and OM of Hypericum perforatum subsp. angustifolium against several clinical strains. The study included 30 patients with candidiasis who had not received any antifungal treatment before they were enrolled. A collection of 30 clinical isolates belonging to 5 different species of Candida spp. was selected for this study. The data obtained showed an interesting activity of both Oil Macerate especially against C. krusei and C. parapsilosis. On the contrary, H. microphyllum Oil Macerate has had a better activity than the H.perforatum especially in relation to C. glabrata and C. krusei.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2018.1557175