Anti-inflammatory activity of coumarins isolated from Tagetes lucida Cav

The anti-inflammatory activity of hexane (TlH) and acetone (TlAc) extracts from the aerial parts of Tagetes lucida were evaluated in a mice model of 12-Ο-Tetradecanoylphorbol 13-Acetate (TPA)-induced auricular oedema. Also, five coumarin compounds from the TlH extract were identified, characterized...

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Bibliographic Details
Published in:Natural product research 2020-11, Vol.34 (22), p.3244-3248
Main Authors: Nayeli, Monterrosas-Brisson, Maribel, Herrera-Ruiz, Enrique, Jiménez-Ferrer, Rafael, Bahena-Pérez, Margarita, Avilés-Flores, Macrina, Fuentes-Mata, Ivan, Martínez-Duncker, Manasés, González-Cortazar
Format: Article
Language:English
Subjects:
Acetic acid
Acetone
Animals
anti-inflammatory activity
Anti-inflammatory agents
Anti-Inflammatory Agents, Non-Steroidal - chemistry
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Chemical activity
Chemical compounds
Coumarin
coumarins
Coumarins - analysis
Coumarins - chemistry
Coumarins - pharmacology
Disease Models, Animal
Drug Evaluation, Preclinical - methods
Edema
Edema - chemically induced
Edema - drug therapy
extract
Inflammation
isoprenyl
Male
Mice, Inbred ICR
Molecular Structure
Plant Components, Aerial - chemistry
Plant Extracts - chemistry
Plant Extracts - pharmacology
Structure-Activity Relationship
Tagetes - chemistry
Tagetes lucida
Tetradecanoylphorbol Acetate - toxicity
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Summary:The anti-inflammatory activity of hexane (TlH) and acetone (TlAc) extracts from the aerial parts of Tagetes lucida were evaluated in a mice model of 12-Ο-Tetradecanoylphorbol 13-Acetate (TPA)-induced auricular oedema. Also, five coumarin compounds from the TlH extract were identified, characterized and evaluated: 7-isoprenyloxycoumarin (1), herniarin (2), 6-methoxy-7-isoprenyloxycoumarin (3), 6,7,8-trimethoxycoumarin (4) and scoparone (5). Compounds 1 and 3 had not been previously identified in T. lucida. Compound 1 showed the highest activity with an 81.1% of oedema inhibition, while 2 reduced it in 54.4%, the other compounds showed less than 50% of inhibitory activity. The chemical structure of the compounds reveal that the substituent at the C-7 position is a crucial factor in exerting the anti-inflammatory activity.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2018.1553172